Comparison of urinary iodine levels in women of childbearing age during and after pregnancy
Por:
Castilla AM, Murcia M, Arrizabalaga JJ, Espada M, Julvez J, Basterrechea M, Alvarez-Pedrerol M, Estarlich M, Moreno E, Guxens M, Vioque J and Rebagliato M
Publicada:
1 ago 2018
Ahead of Print:
29 abr 2017
Resumen:
Median urinary iodine concentration (UIC) is used to describe the iodine status of a population. However, the link between UIC and iodine intake may vary during pregnancy. The aim of this study was to compare UIC during and after pregnancy, adjusting for factors that affect iodine intake.
Two repeated measures of UIC and data on maternal iodine intake estimated through questionnaires were collected during pregnancy and 1-4 years after pregnancy in a subsample of women (n = 598) from a mother and child cohort study in Spain. Random-effects interval regression was used to assess the changes in UIC according to pregnancy status.
Median UIC was similar during (133 mu g/L) and after pregnancy (139 mu g/L). After adjusting for iodised salt, iodine supplement consumption, and socio-demographic related variables, UIC was 24.0% (95% CI 11.3, 38.2) higher after than during pregnancy. This difference was maintained in a subsample of women with exhaustive information on diet (n = 291): 26.2%, 95% CI 10.3, 44.4.
In an iodine sufficient area for the general population, iodine excretion was lower during than after pregnancy when factors affecting iodine intake were controlled for. Current recommendations of median UIC during pregnancy are based on the equivalence between iodine intake and UIC estimated from studies in non-pregnant populations, which might lead to overestimation of iodine deficiency during gestation. Further studies should evaluate the equivalence between iodine intake and its urinary excretion during pregnancy.
Filiaciones:
Castilla AM:
Public Health Laboratory, Basque Government, Bilbao, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain.
Arrizabalaga JJ:
Endocrinology and Nutrition Service, University Hospital of Álava, Basque Health Service, Vitoria Gasteiz, Spain
Espada M:
Public Health Laboratory, Basque Government, Bilbao, Spain
Julvez J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Basterrechea M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Department of Epidemiology, Public Health Division of Gipuzkoa, Basque Government, Gipuzkoa, Spain
Health Research Institute, Biodonostia, San Sebastian, Spain
Alvarez-Pedrerol M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Universitat Pompeu Fabra (UFP), Barcelona, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Moreno E:
Health Centre of Beasain, Basque Health Service, Beasain, Gipuzkoa, Spain
Guxens M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Universitat Pompeu Fabra (UFP), Barcelona, Spain
Vioque J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Department of Public Health, History of Medicine and Gynecology, Universidad Miguel Hernández, San Juan de Alicante, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020, Valencia, Spain
Department of Medicine, University Jaume I, Castelló de la Plana, Spain
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