Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene
Por:
Llop S, Murcia M, Alvarez-Pedrerol M, Grimalt JO, Santa-Marina L, Julvez J, Goñi-Irigoyen F, Espada M, Ballester F, Rebagliato M and Lopez-Espinosa MJ
Publicada:
1 jul 2017
Ahead of Print:
8 abr 2017
Categoría:
Environmental science (miscellaneous)
Resumen:
Introduction: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action.
Aim: To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes.
Methods: The study population (n = 1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003-2006). Hexachlorobenzene (HCB), 1,1-dichloro-2,2-bis(4-chlorophenyl) ethylene (4,4'-DDE), b-hexachlorocyclohexane (b-HCH), polychlorobiphenyl (PCB) congeners 138, 153 and 180, thyroid stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) were measured in serum samples taken during the first trimester of pregnancy (mean [standard deviation (SD)]: 13.5 [2] weeks of gestation). Polymorphisms in DIO1 (rs2235544) and DIO2 (rs12885300) were genotyped in maternal DNA. Sociodemographic and dietary characteristics were obtained by questionnaire.
Results: A 2-fold increase in HCB was associated with lower TT3 (% change = -1.48; 95% CI: -2.36, -0.60). Women in the third tertile for b-HCH had lower TT3 (% change=-3.19; 95% CI:-5.64,-0.67). The interactions between DIO1 rs2235544 and PCB153 and b-HCH were statistically significant. The inverse association between PCB153 and TT3 was the strongest among women with AA genotype. Women with CC genotype presented the strongest inverse association between b-HCH and FT4.
Conclusion: Exposure to HCB and b-HCH was associated to a disruption in maternal TT3. The DIO1 rs2235544 SNP modified the association between exposure to some of the OCs (specifically b-HCH and PCB153) and maternal thyroid hormone levels. These results strengthen the hypothesis that DIO enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs. (C) 2016 Elsevier Ltd. All rights reserved.
Filiaciones:
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Alvarez-Pedrerol M:
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Institut Municipal d'Investigació Mèdica (IMIM)-Hospital del Mar, Barcelona, Spain
Grimalt JO:
Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain
Santa-Marina L:
Biodonostia, Instituto de Investigación Biomédica, San Sebastián, Spain
Departamento de Sanidad Gobierno Vasco, Subdirección de Salud Pública de Gipuzkoa, San Sebastián, Spain
Julvez J:
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Institut Municipal d'Investigació Mèdica (IMIM)-Hospital del Mar, Barcelona, Spain
Goñi-Irigoyen F:
Biodonostia, Instituto de Investigación Biomédica, San Sebastián, Spain
Public Health Laboratory, Basque Government, San Sebastian, Spain
Espada M:
Public Health Laboratory, Basque Government, Bizkaia, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
:
Department of Medicine, Universitat Jaume I, Castello de la Plana, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
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