Manual motor speed dysfunction as a neurocognitive endophenotype in euthymic bipolar disorder patients and their healthy relatives. Evidence from a 5-year follow-up study
Por:
Correa-Ghisays P, Balanzá-Martínez V, Selva-Vera G, Vila-Francés J, Soria-Olivas E, Vivas-Lalinde J, San Martín C, Borrás AM, Ayesa-Arriola R, Sanchez-Moreno J, Sánchez-Ort J, Crespo-Facorro B, Vieta E and Tabarés-Seisdedos R
Publicada:
1 jun 2017
Ahead of Print:
16 mar 2017
Resumen:
Background: Few studies have examined Manual Motor Speed (MMS) in
bipolar disorder (BD). The aim of this longitudinal, family study was to
explore whether dysfunctional MMS represents a neurocognitive
endophenotype of BD.
Methods: A sample of 291 subjects, including 131 BD patients, 77 healthy
first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy
controls (HC), was assessed with the Finger-Tapping Test (En) on three
occasions over a 5-year period. Dependence of FTT on participants' age
was removed by means of a lineal model of HC samples, while correcting
simultaneously the time and learning effect. Differences between groups
were evaluated with an ANOVA test.
Results: The patients' performance was significantly worse than that of
HC over time (p <= 0.006), and these deficits remained when non-euthymic
BD patients (n=9) were excluded from analysis. Some significant
differences between BD patients and BD-Rel (p <= 0.037) and between
BD-Rel and HC (p <= 0.033) were found, but they tended to disappear as
time progressed (p >= 0.057). Performance of the BD-Rel group was
intermediate to that of BD and HC. Most sociodemographic and clinical
variables did not affect these results in patients. (p >= 0.1). However,
treatment with carbamazepine and benzodiazepines may exert a iatrogenic
effect on MMS performance (p <= 0.006).
Limitations: Only right-handed subjects were included in this study.
Substantial attrition over time was detected.
Conclusions: There were significant differences between the patients'
MMS performance and that of healthy relatives and controls, regardless
of most clinical and sociodemographic variables. Dysfunctional MMS could
be considered an endophenotype of BD. Further studies are needed to rule
out possible iatrogenic effects of some psychopharmacological
treatments.
Filiaciones:
Correa-Ghisays P:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Faculty of Psychology, University of Valencia, Valencia, Spain
:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Valencia, Spain
Service of Psychiatry, La Fe University and Polytechnic Hospital, Valencia, Spain
Selva-Vera G:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Valencia, Spain
INCLIVA Health Research Institute, Valencia, Spain
Vila-Francés J:
IDAL - Intelligent Data Analysis Laboratory, University of Valencia, Valencia, Spain
Soria-Olivas E:
IDAL - Intelligent Data Analysis Laboratory, University of Valencia, Valencia, Spain
:
Department of Psychiatry, University Hospital Doctor Peset, Valencia, Spain
San Martín C:
Methodology Department, Behavioral Sciences, University of Valencia, Spain
Borrás AM:
Personality, Evaluation and Psychological Treatment Department, Faculty of Psychology, University of Valencia, Spain
Ayesa-Arriola R:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Department of Psychiatry, School of Medicine, University Hospital Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain
Sanchez-Moreno J:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Bipolar Disorders Unit, Neurosciences Institute, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Catalonia, Spain
Sánchez-Ort J:
Faculty of Psychology, University of Valencia, Valencia, Spain
Crespo-Facorro B:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Department of Psychiatry, IDIVAL, School of Medicine, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain
Vieta E:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Bipolar Disorders Unit, Neurosciences Institute, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Catalonia, Spain
Tabarés-Seisdedos R:
Centro Investigacion Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Valencia, Spain
INCLIVA Health Research Institute, Valencia, Spain.
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