High Mammographic Density in Long-Term Night-Shift Workers: DDM-Spain/Var-DDM
Por:
Pedraza-Flechas AM, Lope V, Sánchez-Contador C, Santamariña C, Pedraz-Pingarrón C, Moreo P, Ederra M, Miranda-García J, Vidal C, Llobet R, Aragonés N, Salas-Trejo D, Pollán M and Pérez-Gómez B
Publicada:
1 jun 2017
Ahead of Print:
23 mar 2017
Resumen:
Background: Night-shift work (NSW) has been suggested as a possible cause of breast cancer, and its association with mammographic density (MD), one of the strongest risk factors for breast cancer, has been scarcely addressed. This study examined NSW and MD in Spanish women.
Methods: The study covered 2,752 women aged 45-68 years recruited in 2007-2008 in 7 population-based public breast cancer screening centers, which included 243 women who had performed NSW for at least one year. Occupational data and information on potential confounders were collected by personal interview. Two trained radiologist estimated the percentage of MD assisted by a validated semiautomatic computer tool (DM-scan). Multivariable mixed linear regression models with random screening center-specific intercepts were fitted using log-transformed percentage of MD as the dependent variable and adjusting by known confounding variables.
Results: Having ever worked in NSW was not associated with MD [e(beta):0.96; 95% confidence interval (CI), 0.86-1.06]. However, the adjusted geometric mean of the percentage of MD in women with NSW for more than 15 years was 25% higher than that of those without NSW history (MD>15 (years):20.7% vs. MDnever:16.5%; e(beta):1.25; 95% CI, 1.01-1.54). This association was mainly observed in postmenopausal participants (e(beta):1.28; 95% CI, 1.00-1.64). Among NSW-exposed women, those with <= 2 night-shifts per week had higher MD than those with 5 to 7 nightshifts per week (e(beta):1.42; 95% CI, 1.10-1.84).
Conclusions: Performing NSW was associated with higherMD only in women with more than 15 years of cumulated exposure. These findings warrant replication in futures studies. (C)2017 AACR.
Filiaciones:
Pedraza-Flechas AM:
Cancer and Environmental Epidemiology Unit, Carlos III Institute of Health
Lope V:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, ISCIII
CIBER en Epidemiología y Salud Pública (CIBEResp)
Sánchez-Contador C:
Balearic Islands Breast Cancer Screening Programme. Health Promotion for women and childhood. General Directorate Public Health and Participation. Regional Authority of Health and Consumer Affairs
Santamariña C:
Galicia Breast Cancer Screening Program, Regional Authority of Health, Galicia Regional Government
Pedraz-Pingarrón C:
Castile-Leon Breast Cancer Screening Program, General Directorate Public Health SACYL
Moreo P:
Aragón Breast Cancer Screening Program. Aragon Health Service
Ederra M:
Navarra Public Health Institute
:
Valencia Breast Cancer Screening Program, General Directorate Public Health
Vidal C:
Cancer Prevention and Control Unit, Catalan Institute of Oncology (ICO)
Llobet R:
Institute of Computer Technology, Universitat Politècnica de València
Aragonés N:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, ISCIII
CIBER en Epidemiología y Salud Pública (CIBEResp)
:
Valencia Breast Cancer Screening Program, General Directorate Public Health
Pollán M:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, ISCIII
CIBER en Epidemiología y Salud Pública (CIBEResp)
Pérez-Gómez B:
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, ISCIII
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