Oxidative Stress Predicts All-Cause Mortality in HIV-Infected Patients
Por:
Masiá M, Padilla S, Fernández M, Rodríguez C, Moreno A, Oteo JA, Antela A, Moreno S, Del Amo J, Gutiérrez F and CoRIS, B
Publicada:
25 abr 2016
Resumen:
Objective
We aimed to assess whether oxidative stress is a predictor of mortality
in HIV-infected patients.
Methods
We conducted a nested case-control study in CoRIS, a contemporary,
multicentre cohort of HIV-infected patients, antiretroviral-naive at
entry, launched in 2004. Cases were patients who died with available
stored plasma samples collected. Two age and sex-matched controls for
each case were selected. We measured F2-isoprostanes (F-2-IsoPs) and
malondialdehyde (MDA) plasma levels in the first blood sample obtained
after cohort engagement.
Results
54 cases and 93 controls were included. Median F-2-IsoPs and MDA levels
were significantly higher in cases than in controls. When adjustment was
performed for age, HIV-transmission category, CD4 cell count and HIV
viral load at cohort entry, and subclinical inflammation measured with
highly-sensitive C-reactive protein (hsCRP), the association of
F-2-IsoPs with mortality remained significant (adjusted OR per 1 log10
increase, 2.34 [1.23-4.47], P = 0.009). The association of MDA with
mortality was attenuated after adjustment: adjusted OR (95% CI) per 1
log10 increase, 2.05 [0.91-4.59], P = 0.080. Median hsCRP was also
higher in cases, and it also proved to be an independent predictor of
mortality in the adjusted analysis: OR (95% CI) per 1 log10 increase,
1.39 (1.01-1.91), P = 0.043; and OR (95% CI) per 1 log10 increase, 1.46
(1.07-1.99), P = 0.014, respectively, when adjustment included F-2-IsoPs
and MDA.
Conclusion
Oxidative stress is a predictor of all-cause mortality in HIV-infected
patients. For plasma F-2-IsoPs, this association is independent of
HIV-related factors and subclinical inflammation.
Filiaciones:
:
Infectious Diseases Unit, Hospital General de Elche, Universidad Miguel Hernández, Alicante, Spain
:
Infectious Diseases Unit, Hospital General de Elche, Universidad Miguel Hernández, Alicante, Spain
:
Infectious Diseases Research Laboratory, Hospital General de Elche, Alicante, Spain
Rodríguez C:
HIV/AIDS and Sexually Transmitted Diseases Clinic, Centro Sanitario Sandoval, Madrid, Spain
Moreno A:
Infectious Diseases Service, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
Oteo JA:
Infectious Diseases Service, Hospital San Pedro de La Rioja, Logroño, Spain
Antela A:
Infectious Diseases Unit, Hospital Clínico de Santiago, La Coruña, Spain
Moreno S:
Infectious Diseases Service, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
Del Amo J:
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain
:
Infectious Diseases Unit, Hospital General de Elche, Universidad Miguel Hernández, Alicante, Spain
Open Access
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