The relationship of salivary testosterone and male sexual dysfunction in opioid-associated androgen deficiency (OPIAD)


Por: Ajo R, Segura A, Mira L, Inda MD, Alfayate R, Sánchez-Barbie A, Margarit C and Peiro, A

Publicada: 1 mar 2017 Ahead of Print: 18 oct 2016
Resumen:
Background: Opioids are an effective treatment for chronic non-malignant pain (CNP). Long-term use risks and side effects such as opioid-induced androgen deficiency (OPIAD) exist. This could be measured by saliva testosterone (Sal-T).Objectives: To evaluate OPIAD in long-term opioid use in CNP patients.Methods: A cross-sectional study included CNP male outpatients under opioid treatment. Total-Testosterone (Total-T), Free-Testosterone (Free-T), Bio-Testosterone (Bio-T) and Sal-T were measured. Correlations were calculated by Spearman's rho (SPSS 20).Results: From 2012 to 2014, 134 from 249 (54%) consecutive male outpatients reported erectile dysfunction (ED), 37% of them related to opioids and 19% evidenced OPIAD. A total of 120 subjects (94 cases and 26 matched-controls) were included. A significantly lower luteinizing hormone, Total-T and Free-T were found, as well as, a significant correlation between Sal-T and Total-T (r=0.234, p=0.039), Bio-T (r=0.241, p=0.039), IIEF (r=0.363, p=0.003) and HAD-anxiety (r =-0.414, p=0.012) in OPIAD patients. Sal-T levels were significantly lower in patients with severe-moderate ED versus mild ED (p=0.045) and in patients with severe ED versus moderate-mild ED (p=0.036).Conclusions: These data demonstrate the high prevalence of ED in long-term use of opioids, part of this is associated to OPIAD, which can be tested by Sal-T as a non-invasive approach.

Filiaciones:
Ajo R:
 a Research Unit, Foundation for the Promotion of Health Research and Biomedicine of Valencia (FISABIO) , Alicante , Spain

Segura A:
 b Andrology Unit, University General Hospital of Alicante (HGUA) , Alicante , Spain

:
 c Occupational Observatory, University Miguel Hernández of Elche (UMH) , Alicante , Spain

Inda MD:
 a Research Unit, Foundation for the Promotion of Health Research and Biomedicine of Valencia (FISABIO) , Alicante , Spain

Alfayate R:
 d Hormones Laboratory, HGUA , Alicante , Spain

Sánchez-Barbie A:
 e Computational Research Center, UMH , Alicante , Spain

Margarit C:
 f Pain Unit, HGUA , Alicante , Spain , and

Peiro, A:
 a Research Unit, Foundation for the Promotion of Health Research and Biomedicine of Valencia (FISABIO) , Alicante , Spain

 g Clinical Pharmacology, HGUA , Alicante , Spain
ISSN: 13685538





Aging Male
Editorial
TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 20 Número: 1
Páginas: 1-8
WOS Id: 000399555800001
ID de PubMed: 27750480

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