Primary Breast Lymphoma: Analysis of 55 Cases of the Spanish Lymphoma Oncology Group
Por:
Pérez FF, Lavernia J, Aguiar-Bujanda D, Miramón J, Gumá J, Álvarez R, Gómez-Codina J, Arroyo FG, Llanos M, Marin M, Alfaro J, Quero C, Delgado M, Nogales E, Menarguez F, Martínez N, Torrente M, Royuela A, Abreu D and Provencio M
Publicada:
1 mar 2017
Ahead of Print:
17 sep 2016
Resumen:
We reviewed 55 patients diagnosed with primary breast lymphoma, stages
IE and IIE, in 16 Spanish institutions. Of the 55 cases, 96.4%
corresponded to non-Hodgkin lymphoma. Results of 5-year progression-free
and overall survival were 73% and 76%, respectively. Current treatments
achieve good control of the disease, with an overall survival of 5 years
in 80% of the patients.
Introduction: Primary breast lymphoma is a rare form of localized
extranodal lymphoma, which affects the mammary glands unilaterally or
bilaterally, and can also affect the regional lymph nodes. Materials and
Methods: We reviewed 55 patients, with disease stages IE and IIE,
diagnosed in 16 Spanish institutions between 1989 and 2016. A serial of
clinical variables and treatment were collected, and overall survival
(OS) and progression-free survival (PFS) were calculated. Results: Of
the 55 patients, 96.4% were women with an average age of 69 years. A
total of 53 patients corresponded to non-Hodgkin lymphoma (NHL), of whom
36.3% had lymph node involvement upon diagnosis. Of the patients, 58.2%
were stage IE, and 41.8% were stage IIE. Treatments received included
radiotherapy (36.3%), chemotherapy (85.5%), and rituximab (in 38 of the
45 patients with NHL treated with chemotherapy). In all, 82.2% of
complete responses were achieved. OS and progression-free survival at 5
years in NHL patients was 76% and 73%, respectively. Conclusion: Current
treatments (chemotherapy, immunotherapy, and radiotherapy) achieve good
control of the disease, with an OS of 5 years in 80% of the patients,
although there is no consensus in treatment, given the scarce incidence
of these lymphomas. (C) 2016 The Authors. Published by Elsevier Inc.
Filiaciones:
Pérez FF:
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
Lavernia J:
Department of Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain
Aguiar-Bujanda D:
Department of Medical Oncology, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canarias, Spain
Miramón J:
Department of Medical Oncology, Hospital Serranía de Ronda, Málaga, Spain
Gumá J:
Department of Medical Oncology, Hospital Universitari Sant Joan de Reus, Reus, Spain
Álvarez R:
Department of Medical Oncology, Hospital Universitario Virgen de la Salud, Toledo, Spain
Gómez-Codina J:
Department of Medical Oncology, Hospital Universitari i Politècnic La Fe, Valencia, Spain
Arroyo FG:
Department of Medical Oncology, Complejo Hospitalario de Pontevedra, Pontevedra, Spain
Llanos M:
Department of Medical Oncology, Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain
Marin M:
Department of Medical Oncology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
Alfaro J:
Department of Medical Oncology, Instituto Oncológico de Kutxa, Donistia, Spain
Quero C:
Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Málaga, Spain
Delgado M:
Department of Medical Oncology, Hospital Universitario San Cecilio, Granada, Spain
Nogales E:
Department of Medical Oncology, Hospital Universitario Virgen de la Macarena, Sevilla, Spain
:
Department of Medical Oncology, Hospital General Universitario de Elche, Alicante, Spain
Martínez N:
Department of Medical Oncology, Hospital General Universitario de Elche, Alicante, Spain
Torrente M:
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain
Royuela A:
Department of Biostatistics, Hospital Universitario Puerta de Hierro, Majadahonda, Spain
Abreu D:
Department of Medical Oncology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canarias, Spain
Provencio M:
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain
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