MR Imaging Findings in Molecular Subtypes of Breast Cancer According to BIRADS System
Por:
Navarro Vilar L, Alandete Germán SP, Medina García R, Blanc García E, Camarasa Lillo N and Vilar Samper J
Publicada:
1 jul 2017
Ahead of Print:
9 ene 2017
Resumen:
To evaluate magnetic resonance imaging (MRI) findings, according to
Breast Imaging-Reporting and Data System (BI-RADS), and to relate them
with molecular subtypes of breast cancer. The MRI findings were reviewed
retrospectively in 201 women diagnosed of invasive breast cancer
confirmed by surgery and were compared with the molecular subtypes.
Following the BI-RADS, MRI findings included disease type, size,
enhancement, morphology and contrast kinetics. In mass-like lesion types
were studied shape, margin and enhancement, and in nonmass-like lesion
types, distribution modifiers and internal enhancement. Chi-squared
analysis showed significant association (p < 0.01) between molecular
subtypes and lesion type on MRI and histologic grade. Shape, margin and
mass enhancement (p < 0.05) also showed significant association among
molecular subtypes. Triple negative were more frequently unifocal and
mass-like lesion, high histologic grade, round shape, smooth margin, and
rim enhancement. Luminal-A were more frequently low grade, mass-like
lesion, irregular shape and spiculated or irregular margin. Luminal-B
were more frequently moderate-low grade, mass-like lesion, nonirregular
shape and spiculated margin. HER-2-enriched were more frequently
moderate grade, nonmass-like lesion and multicentric lesions were more
present than in other subtypes. There are significantly different MRI
features, according to BI-RADS, between the molecular subtypes breast
cancer.
Filiaciones:
:
Department of Radiology, Hospital Lluis Alcanyis de Xàtiva, Xàtiva, Spain
:
Department of Radiology, Hospital Doctor Peset, Valencia, Spain
:
Department of Radiology, Hospital Doctor Peset, Valencia, Spain
:
Department of Radiology, Hospital Doctor Peset, Valencia, Spain
:
Department of Pathology, Hospital Doctor Peset, Valencia, Spain
:
Department of Radiology, Hospital Doctor Peset, Valencia, Spain
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