Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients.
Por:
Redondo F, Hurtado-Marcos C, Izquierdo F, Cuéllar C, Fenoy S, Sáez Y, Magnet Á, Galindo-Regal L, Uribe N, López-Bañeres M, Jiménez AI, Llombart-Cussac A, Del Águila C and Andreu-Ballester JC
Publicada:
29 oct 2022
Ahead of Print:
29 oct 2022
Resumen:
Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p < 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.
Filiaciones:
Redondo F:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
Hurtado-Marcos C:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
Izquierdo F:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
Cuéllar C:
Department of Microbiology and Parasitology, Complutense University, 28040 Madrid, Spain
Fenoy S:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
Sáez Y:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
Magnet Á:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
:
Molecular Biologist, Laboratory of Molecular Biology and Research Department, Arnau de Vilanova University Hospital, FISABIO Foundation, 46015 Valencia, Spain
:
Department of General and Digestive Surgery, Arnau de Vilanova University Hospital, 46015 Valencia, Spain
:
Department of General and Digestive Surgery, Arnau de Vilanova University Hospital, 46015 Valencia, Spain
:
Pathology Department, Arnau de Vilanova University Hospital, 46015 Valencia, Spain
:
Medical Oncology Department, Arnau de Vilanova Hospital, Catholic University of Valencia, 46015 Valencia, Spain
Del Águila C:
Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain
:
FISABIO Foundation and Research Department, Arnau de Vilanova University Hospital, c/San Clemente 12, 46015 Valencia, Spain
Green Published, gold
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