Distribution and prognosis of molecular breast cancer subtypes defined by immunohistochemical biomarkers in a Spanish population-based study
Por:
Puig-Vives, M, Sanchez, M, Sanchez-Cantalejo, J, Torrella-Ramos, A, Martos, C, Ardanaz, E, Chirlaque, M, Perucha, J, Diaz, J, Mateos, A, Machon, M and Marcos-Gragera, R
Publicada:
1 sep 2013
Resumen:
Background. The objective of this study is to analyze the distribution, clinicopathological features, relative survival rate and excess risk of death among females diagnosed with invasive breast cancer and classified by molecular subtype from ten Spanish cancer registries.
Method. Three thousand four hundred and eighty incident cases of women - mostly diagnosed in 2005 - were classified into five molecular subtypes according to immunohistochemical status of hormonal receptors and HER2 (human epidermal growth factor receptor 2): estrogen receptor (ER) and/or progesterone receptor (PR)+ and HER2-, ER+ and/or PR+ and HER2+, HER2-overexpressed (ER-, PR- and HER2+), triple negative (ER, PR and HER2-) and unclassified (hormonal receptor or/and HER2 unknown). Relative survival rates at 1, 3 and 5 years and relative excess risks (RER) of death adjusting for molecular subtype, age, stage and histological grade were estimated.
Results. Marked differences in clinicopathological characteristics and relative survival rate were observed between molecular subtypes. Compared with Women with ER+ and/or PR+ and HER2-, ER+ and/or PR+ and HER2 + cases had an RER of 1.00 (95% CI: 0.66 to 1.52) after adjusting for age, stage and histological grade, whereas HER2-overexpressed, triple negative and women with unclassified subtypes presented an RER of 1.72 (95% Cl: 1.15 to 2.57), 3.16 (95% CI: 2.26 to 4.41) and 2.55 (95% CI: 1.96 to 3.32), respectively.
Conclusion. The prognostic value of molecular subtype persists when adjusting for age, stage and histological grade. Hormone receptor-positive tumors were associated with a better prognosis when compared with HER2-overexpressed and triple negative subtypes. Further research is required to improve triple negative prognosis. (C) 2013 Elsevier Inc. All rights reserved.
Filiaciones:
Puig-Vives, M:
Epidemiol Unit, Girona, Spain
Girona Canc Registry UERCG, Girona, Spain
Girona Biomed Res Inst IDIBGI, Girona, Spain
Univ Girona, Res Grp Stat Econometr & Hlth GRECS, Girona 17004, Spain
Sanchez, M:
Granada Canc Registry, Andalusian Sch Publ Hlth, Granada, Spain
Sanchez-Cantalejo, J:
Granada Canc Registry, Andalusian Sch Publ Hlth, Granada, Spain
Torrella-Ramos, A:
Castellon Canc Registry, Castellon de La Plana, Spain
Ctr Publ Hlth Res, Valencia, Spain
:
Ctr Publ Hlth Res, Valencia, Spain
Ardanaz, E:
Navarra Publ Hlth Inst, Navarra Canc Registry, Pamplona, Spain
Chirlaque, M:
Murcia Canc Registry, Dept Epidemiol, Reg Hlth Author, Murcia, Spain
Perucha, J:
La Rioja Canc Registry, La Rioja, Spain
Diaz, J:
Cuenca Canc Registry, Cuenca, Spain
Mateos, A:
Albacete Canc Registry, Hlth & Social Welf Author, Castilla La Mancha, Spain
Machon, M:
Publ Hlth Dept Gipuzkoa, San Sebastian, Spain
Marcos-Gragera, R:
Epidemiol Unit, Girona, Spain
Girona Canc Registry UERCG, Girona, Spain
Girona Biomed Res Inst IDIBGI, Girona, Spain
Univ Girona, Res Grp Stat Econometr & Hlth GRECS, Girona 17004, Spain
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