Impact of Systemic Comorbidities on Ocular Hypertension and Open-Angle Glaucoma, in a Population from Spain and Portugal
Por:
Garcia-Villanueva C, Milla E, Bolarin JM, García-Medina JJ, Cruz-Espinosa J, Benítez-Del-Castillo J, Salgado-Borges J, Hernández-Martínez FJ, Bendala-Tufanisco E, Andrés-Blasco I, Gallego-Martinez A, Zanón-Moreno VC and Pinazo-Durán MD
Publicada:
1 oct 2022
Ahead of Print:
25 sep 2022
Categoría:
Medicine (miscellaneous)
Resumen:
Open-angle glaucoma (OAG), the most prevalent clinical type of glaucoma, is still the main cause of irreversible blindness worldwide. OAG is a neurodegenerative illness for which the most important risk factor is elevated intraocular pressure (IOP). Many questions remain unanswered about OAG, such as whether nutritional or toxic habits, other personal characteristics, and/or systemic diseases influence the course of glaucoma. As such, in this study, we performed a multicenter analytical, observational, case-control study of 412 participants of both sexes, aged 40-80 years, that were classified as having ocular hypertension (OHT) or OAG. Our primary endpoint was to investigate the relationship between specific lifestyle habits; anthropometric and endocrine-metabolic, cardiovascular, and respiratory events; and commonly used psychochemicals, with the presence of OHT or OAG in an ophthalmologic population from Spain and Portugal. Demographic, epidemiological, and ocular/systemic clinical data were recorded from all participants. Data were analyzed using the R Statistics v4.1.2 and RStudio v2021.09.1 programs. The mean age was 62 +/- 15 years, with 67-80 years old comprising the largest subgroup sample of participants in both study groups. The central corneal thickness (ultrasound pachymetry)-adjusted IOP (Goldman tonometry) in each eye was 20.46 +/- 2.35 and 20.1 +/- 2.73 mmHg for the OHT individuals, and 15.8 +/- 3.83 and 16.94 +/- 3.86 mmHg for the OAG patients, with significant differences between groups (both p = 0.001). The highest prevalence of the surveyed characteristics in both groups was for overweight/obesity and daily coffee consumption, followed by psychochemical drug intake, migraine, and peripheral vasospasm. Our data show that overweight/obesity, migraine, asthma, and smoking are major risk factors for conversion from OHT to OAG in this Spanish and Portuguese population.
Filiaciones:
:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Department of Ophthalmology, University General Hospital, 46014 Valencia, Spain
Milla E:
Department of Ophthalmology, Clinic Hospital, 08036 Barcelona, Spain
Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, 28029 Madrid, Spain
Bolarin JM:
Technological Centre of Information and Communication Technologies (CENTIC), 30100 Murcia, Spain
García-Medina JJ:
Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, 28029 Madrid, Spain
Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain
Department of Ophthalmology, The General University Hospital "Morales Meseguer", Ave/Marques de los Velez s/n, 30008 Murcia, Spain
Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain
Cruz-Espinosa J:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Department of Ophthalmology, Punta de Europa Hospital, 11207 Algeciras, Spain
Benítez-Del-Castillo J:
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, 28029 Madrid, Spain
Department of Ophthalmology, Jerez Hospital, 11407 Jerez de la Frontera, Spain
Salgado-Borges J:
Department of Ophthalmology, Clinsborges, 4000-422 Porto, Portugal
Hernández-Martínez FJ:
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Department of Ophthalmology, San Juan de Dios Hospital, 41930 Sevilla, Spain
:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Department of Ophthalmology, Clinic Hospital, 08036 Barcelona, Spain
Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain
Department of Biomedical Sciences, Faculty of Health Sciences, University Cardenal Herrera CEU, 46115 Valencia, Spain
:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain
:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, 28029 Madrid, Spain
Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain
Faculty of Health Sciences, Valencian International University-VIU, 46002 Valencia, Spain
:
Ophthalmic Research Unit "Santiago Grisolia", FISABIO (Foundation for Research in Health and Biomedicine), 46017 Valencia, Spain
Cellular and Molecular Ophthalmobiology Group, Surgery Department, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, 28029 Madrid, Spain
Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain
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