Gut Microbiota as a Potential Predictive Biomarker in Relapsing-Remitting Multiple Sclerosis
Por:
Navarro-Lopez, V, Mendez-Miralles, M, Vela-Yebra, R, Fries-Ramos, A, Sanchez-Pellicer, P, Ruzafa-Costas, B, Nunez-Delegido, E, Gomez-Gomez, H, Chumillas-Lidon, S, Pico-Monllor, J and Navarro-Moratalla, L
Publicada:
1 may 2022
Resumen:
Background: The influence of the microbiome on neurological diseases has been studied for years. Recent findings have shown a different composition of gut microbiota detected in patients with multiple sclerosis (MS). The role of this dysbiosis is still unknown. Objective: We analyzed the gut microbiota of 15 patients with active relapsing-remitting multiple sclerosis (RRMS), comparing with diet-matched healthy controls. Method: To determine the composition of the gut microbiota, we performed high-throughput sequencing of the 16S ribosomal RNA gene. The specific amplified sequences were in the V3 and V4 regions of the 16S ribosomal RNA gene. Results: The gut microbiota of RRMS patients differed from healthy controls in the levels of the Lachnospiraceae, Ezakiella, Ruminococcaceae, Hungatella, Roseburia, Clostridium, Shuttleworthia, Poephyromonas, and Bilophila genera. All these genera were included in a logistic regression analysis to determine the sensitivity and the specificity of the test. Finally, the ROC (receiver operating characteristic) and AUC with a 95% CI were calculated and best-matched for Ezakiella (AUC of 75.0 and CI from 60.6 to 89.4) and Bilophila (AUC of 70.2 and CI from 50.1 to 90.4). Conclusions: There is a dysbiosis in the gut microbiota of RRMS patients. An analysis of the components of the microbiota suggests the role of some genera as a predictive factor of RRMS prognosis and diagnosis.
Filiaciones:
:
UCAM Univ Catolica San Antonio Murcia, PhD Program Hlth Sci, Campus Jeronimos 135, Murcia 30107, Spain
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Univ Hosp Vinalopo, Infect Dis Unit, Carrer Tonico Sansano Mora 14, Elche 03293, Spain
Mendez-Miralles, M:
UCAM Univ Catolica San Antonio Murcia, PhD Program Hlth Sci, Campus Jeronimos 135, Murcia 30107, Spain
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Univ Hosp Torrevieja, Dept Neurol, Carretera CV95 S-N, Alicante 03186, Spain
:
Univ Hosp Torrevieja, Dept Neurol, Carretera CV95 S-N, Alicante 03186, Spain
:
Univ Hosp Vinalopo, Dept Neurol, Carrer Ton Sansano Mora 14, Elche 03293, Spain
Sanchez-Pellicer, P:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Ruzafa-Costas, B:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Nunez-Delegido, E:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Gomez-Gomez, H:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Chumillas-Lidon, S:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Pico-Monllor, J:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
Univ Miguel Hernandez Elche, Fac Pharm, Dept Pharmacol Pediat & Organ Chem, Elche 03202, Spain
Navarro-Moratalla, L:
UCAM Univ Catolica San Antonio Murcia, Dept Clin Med, MiBioPath Res Grp, Campus Jeronimos 135, Murcia 30107, Spain
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