Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial
Por:
Perez-Lopez, C, Hernandez-Vara, J, Caballol, N, Bayes, A, Buongiorno, M, Lopez-Ariztegui, N, Gironell, A, Lopez-Sanchez, J, Martinez-Castrillo, J, Sauco, M, Lopez-Manzanares, L, Escalante-Arroyo, S, Perez-Martinez, D and Rodriguez-Molinero, A
Publicada:
16 may 2022
Resumen:
Background: For specialists in charge of Parkinson's disease (PD), one of the most time-consuming tasks of the consultations is the assessment of symptoms and motor fluctuations. This task is complex and is usually based on the information provided by the patients themselves, which in most cases is complex and biased. In recent times, different tools have appeared on the market that allow automatic ambulatory monitoring. The MoMoPa-EC clinical trial (NCT04176302) investigates the effect of one of these tools-Sense4Care's STAT-ON-can have on routine clinical practice. In this sub-analysis the agreement between the Hauser diaries and the STAT-ON sensor is analyzed. Methods: Eighty four patients from MoMoPa-EC cohort were included in this sub-analysis. The intraclass correlation coefficient was calculated between the patient diary entries and the sensor data. Results: The intraclass correlation coefficient of both methods was 0.57 (95% CI: 0.3-0.73) for the OFF time (%), 0.48 (95% CI: 0.17-0.68) for the time in ON (%), and 0.65 (95% CI%: 0.44-0.78) for the time with dyskinesias (%). Furthermore, the Spearman correlations with the UPDRS scale have been analyzed for different parameters of the two methods. The maximum correlation found was -0.63 (p < 0.001) between Mean Fluidity (one of the variables offered by the STAT-dON) and factor 1 of the UPDRS. Conclusion: This sub-analysis shows a moderate concordance between the two tools, it is clearly appreciated that the correlation between the different UPDRS indices is better with the STAT-ON than with the Hauser diary.
Filiaciones:
Perez-Lopez, C:
Dept Invest, Consorci Sanit Alt Penedes & Garraf, St Pere Ribes, Spain
Hernandez-Vara, J:
Inst Salud Carlos III, Biomed Res Network Ctr Neurodegenerat Dis CIBERNED, Vall Hebron Inst RecercaUnivers Autonoma Barcelona, Neurol Dept, Madrid, Spain
Caballol, N:
Hosp St Joan Despi Moises Broggi, Dept Neurol, St Joan Despi, Spain
Hosp Quiron Teknon, Parkinsons & Movement Disorders Unit, Barcelona, Spain
Bayes, A:
Hosp Quiron Teknon, Parkinsons & Movement Disorders Unit, Barcelona, Spain
Buongiorno, M:
Hosp Universitari Mutua Terrassa, Dept Neurol, Barcelona, Spain
Lopez-Ariztegui, N:
Hosp Univ Toledo, Dept Neurol, Toledo, Spain
Gironell, A:
Hosp St Creu I St Pau, Dept Neurol, Barcelona, Spain
Lopez-Sanchez, J:
Hosp Virgen Arrixaca Murcia, Dept Neurol, Murcia, Spain
Martinez-Castrillo, J:
Hosp Ramon & Cajal, Movement Disorders & Neurodegenerat Dis Unit, IRYCIS, Madrid, Spain
:
Hosp Gen Elche, Dept Neurol, Elche, Spain
Lopez-Manzanares, L:
Hosp Univ Princesa, Dept Neurol, Madrid, Spain
Escalante-Arroyo, S:
Hosp Tortosa Verge Cinta, Dept Neurol, Tortosa, Spain
Perez-Martinez, D:
Hosp Univ 12 Octubre, Neurol Serv, Madrid, Spain
Rodriguez-Molinero, A:
Dept Invest, Consorci Sanit Alt Penedes & Garraf, St Pere Ribes, Spain
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