Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use: A Sub-analysis of the MoMoPa-EC Clinical Trial


Por: Perez-Lopez, C, Hernandez-Vara, J, Caballol, N, Bayes, A, Buongiorno, M, Lopez-Ariztegui, N, Gironell, A, Lopez-Sanchez, J, Martinez-Castrillo, J, Sauco, M, Lopez-Manzanares, L, Escalante-Arroyo, S, Perez-Martinez, D and Rodriguez-Molinero, A

Publicada: 16 may 2022
Resumen:
Background: For specialists in charge of Parkinson's disease (PD), one of the most time-consuming tasks of the consultations is the assessment of symptoms and motor fluctuations. This task is complex and is usually based on the information provided by the patients themselves, which in most cases is complex and biased. In recent times, different tools have appeared on the market that allow automatic ambulatory monitoring. The MoMoPa-EC clinical trial (NCT04176302) investigates the effect of one of these tools-Sense4Care's STAT-ON-can have on routine clinical practice. In this sub-analysis the agreement between the Hauser diaries and the STAT-ON sensor is analyzed. Methods: Eighty four patients from MoMoPa-EC cohort were included in this sub-analysis. The intraclass correlation coefficient was calculated between the patient diary entries and the sensor data. Results: The intraclass correlation coefficient of both methods was 0.57 (95% CI: 0.3-0.73) for the OFF time (%), 0.48 (95% CI: 0.17-0.68) for the time in ON (%), and 0.65 (95% CI%: 0.44-0.78) for the time with dyskinesias (%). Furthermore, the Spearman correlations with the UPDRS scale have been analyzed for different parameters of the two methods. The maximum correlation found was -0.63 (p < 0.001) between Mean Fluidity (one of the variables offered by the STAT-dON) and factor 1 of the UPDRS. Conclusion: This sub-analysis shows a moderate concordance between the two tools, it is clearly appreciated that the correlation between the different UPDRS indices is better with the STAT-ON than with the Hauser diary.

Filiaciones:
Perez-Lopez, C:
 Dept Invest, Consorci Sanit Alt Penedes & Garraf, St Pere Ribes, Spain

Hernandez-Vara, J:
 Inst Salud Carlos III, Biomed Res Network Ctr Neurodegenerat Dis CIBERNED, Vall Hebron Inst RecercaUnivers Autonoma Barcelona, Neurol Dept, Madrid, Spain

Caballol, N:
 Hosp St Joan Despi Moises Broggi, Dept Neurol, St Joan Despi, Spain

 Hosp Quiron Teknon, Parkinsons & Movement Disorders Unit, Barcelona, Spain

Bayes, A:
 Hosp Quiron Teknon, Parkinsons & Movement Disorders Unit, Barcelona, Spain

Buongiorno, M:
 Hosp Universitari Mutua Terrassa, Dept Neurol, Barcelona, Spain

Lopez-Ariztegui, N:
 Hosp Univ Toledo, Dept Neurol, Toledo, Spain

Gironell, A:
 Hosp St Creu I St Pau, Dept Neurol, Barcelona, Spain

Lopez-Sanchez, J:
 Hosp Virgen Arrixaca Murcia, Dept Neurol, Murcia, Spain

Martinez-Castrillo, J:
 Hosp Ramon & Cajal, Movement Disorders & Neurodegenerat Dis Unit, IRYCIS, Madrid, Spain

:
 Hosp Gen Elche, Dept Neurol, Elche, Spain

Lopez-Manzanares, L:
 Hosp Univ Princesa, Dept Neurol, Madrid, Spain

Escalante-Arroyo, S:
 Hosp Tortosa Verge Cinta, Dept Neurol, Tortosa, Spain

Perez-Martinez, D:
 Hosp Univ 12 Octubre, Neurol Serv, Madrid, Spain

Rodriguez-Molinero, A:
 Dept Invest, Consorci Sanit Alt Penedes & Garraf, St Pere Ribes, Spain
ISSN: 16642295





Frontiers in Neurology
Editorial
FRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 13 Número:
Páginas:
WOS Id: 000805644700001
ID de PubMed: 35651347
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