Dietary inflammatory index and prostate cancer risk: MCC-Spain study
Por:
Lozano-Lorca M, Salcedo-Bellido I, Olmedo-Requena R, Castaño-Vinyals G, Amiano P, Shivappa N, Hébert JR, Pérez-Gómez B, Gracia-Lavedan E, Gómez-Acebo I, Molina-Barceló A, Barrios-Rodríguez R, Alguacil J, Fernández-Tardón G, Aragonés N, Dierssen-Sotos T, Romaguera D, Pollán M, Kogevinas M and Jiménez-Moleón JJ
Publicada:
1 sep 2022
Ahead of Print:
1 abr 2022
Resumen:
BACKGROUND: The etiology of prostate cancer (PCa) is not well-known, and the role of diet is not well established. We aimed to evaluate the role of the inflammatory power of the diet, measured by the Dietary Inflammatory Index (DII (R)), on the risk of PCa.
METHODOLOGY: A population-based multicase-control (MCC-Spain) study was conducted. Information was collected on sociodemographic characteristics, personal and family antecedents, and lifestyles, including diet from a Food Frequency Questionnaire. The inflammatory potential of the diet was assessed using the energy-adjusted Dietary Inflammatory Index (E-DII) based on 30 parameters (a higher score indicates a higher inflammatory capacity of the diet). Tertiles of E-DII were created using the cut-off points from the control group. The International Society of Urology Pathology (ISUP) was grouped as ISUP 1, ISUP 2, or ISUP 3-5. Unconditional logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between E-DII score and PCa risk.
RESULTS: A total of 928 PCa cases and 1278 population controls were included. Among PCa cases, the mean value of the E-DII score was 0.18 (SD: 1.9) vs. 0.07 (SD: 1.9) in the control group (p = 0.162). Cases with a more pro-inflammatory diet (3rd tertile) had the highest risk of PCa, aOR(T3vsT1) = 1.30 (95% CI 1.03-1.65) (p-trend = 0.026). When stratifying by ISUP, this risk association was observed only for ISUP 2 and ISUP 3-5, aOR(T3vsT1) = 1.46 (95% CI 1.02-2.10) and 1.60 (95% CI 1.10-2.34), respectively.
CONCLUSION: A positive association was observed between consuming a pro-inflammatory diet and PCa in the MCC-Spain population, specifically for an ISUP grade greater or equal than 2.
Filiaciones:
Lozano-Lorca M:
Universidad de Granada. Departamento de Medicina Preventiva y Salud Pública, Granada, Spain
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
Salcedo-Bellido I:
Universidad de Granada. Departamento de Medicina Preventiva y Salud Pública, Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain.
Olmedo-Requena R:
Universidad de Granada. Departamento de Medicina Preventiva y Salud Pública, Granada, Spain
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Castaño-Vinyals G:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Instituto de Salud Global de Barcelona (ISGlobal), Barcelona, Spain
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Amiano P:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Public Health Division of Gipuzkoa, Donostia-San Sebastian, Spain
Shivappa N:
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Hébert JR:
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Pérez-Gómez B:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Department of Epidemiology for Chronic Diseases, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
Gracia-Lavedan E:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Instituto de Salud Global de Barcelona (ISGlobal), Barcelona, Spain
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain
Gómez-Acebo I:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Department of Preventive Medicine and Public Health, University of Cantabria-IDIVAL, 39011, Santander, Spain
:
Cancer and Public Health Area, FISABIO-Public Health, Valencia, Spain
Barrios-Rodríguez R:
Universidad de Granada. Departamento de Medicina Preventiva y Salud Pública, Granada, Spain
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Alguacil J:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain
Fernández-Tardón G:
Health Research Institute of the Principality of Asturias (ISPA), Oncology Institute, University of Oviedo, Oviedo, Asturias, Spain
Department of Medicine, University of Oviedo, Oviedo, Spain
Aragonés N:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Epidemiology Section, Division of Public Health, Department of Health, Madrid, Spain
Dierssen-Sotos T:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Department of Preventive Medicine and Public Health, University of Cantabria-IDIVAL, 39011, Santander, Spain
Romaguera D:
Instituto de Salud Global de Barcelona (ISGlobal), Barcelona, Spain
Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain
Consortium for Biomedical Research in Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Pollán M:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Department of Epidemiology for Chronic Diseases, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
Kogevinas M:
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain
Instituto de Salud Global de Barcelona (ISGlobal), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
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