Lung function and radiological findings 1 year after COVID-19: a prospective follow-up
Por:
Tarraso J, Safont B, Carbonell-Asins JA, Fernandez-Fabrellas E, Sancho-Chust JN, Naval E, Amat B, Herrera S, Ros JA, Soler-Cataluña JJ, Rodriguez-Portal JA, Andreu AL, Marín M, Rodriguez-Hermosa JL, Gonzalez-Villaescusa C, Soriano JB and Signes-Costa J
Publicada:
12 sep 2022
Ahead of Print:
12 sep 2022
Categoría:
Pulmonary and respiratory medicine
Resumen:
Background The coronavirus disease (COVID-19) pandemic has already affected more than 400 million people, with increasing numbers of survivors. These data indicate that a myriad of people may be affected by pulmonary sequelae of the infection. The aim of this study was to evaluate pulmonary sequelae in patients with bilateral COVID-19 pneumonia according to severity 1 year after hospital discharge. Methods COVID-FIBROTIC is a multicenter prospective observational cohort study for admitted patients with bilateral COVID-19 pneumonia. Pulmonary functional outcomes and chest computed tomography sequelae were analyzed 12 months after hospital discharge and we classified patients into three groups according to severity. A post hoc analysis model was designed to establish how functional test changed between groups and over time. A multivariable logistic regression model was created to study prognostic factors for lung diffusion impairment and radiological fibrotic-like changes at 12 months. Results Among 488 hospitalized patients with COVID-19 pneumonia, 284 patients had completed the entire evaluation at 12 months. Median age was 60.5 +/- 11.9 and 55.3% were men. We found between-group differences in male sex, length of hospital stay, radiological involvement and inflammatory laboratory parameters. The functional evaluation of pulmonary sequelae showed that severe patients had statistically worse levels of lung diffusion at 2 months but no between group differences were found in subsequent controls. At 12-month follow up, however, we found impaired lung diffusion in 39.8% unrelated to severity. Radiological fibrotic-like changes at 12 months were reported in 22.7% of patients (102/448), only associated with radiological involvement at admission (OR: 1.55, 95% CI 1.06-2.38; p = 0.02) and LDH (OR: 0.99, 95% CI 0.98-0.99; p = 0.046). Conclusion Our data suggest that a significant percentage of individuals would develop pulmonary sequelae after COVID 19 pneumonia, regardless of severity of the acute process. Trial registration clinicaltrials.gov NCT04409275 (June 1, 2020)
Filiaciones:
Tarraso J:
Pulmonary Department, Hospital Clinico, INCLIVA, Valencia, Spain
Safont B:
Pulmonary Department, Hospital Clinico, INCLIVA, Valencia, Spain
Carbonell-Asins JA:
Bioinformatics and Biostatistics Unit, INCLIVA, Valencia, Spain
Fernandez-Fabrellas E:
Pulmonary Department, Hospital General, Valencia, Spain
:
Pulmonary Department, Hospital San Juan, Alicante, Spain
:
Pulmonary Department, Hospital La Ribera, Alzira, Valencia, Spain
:
Pulmonary Department, Hospital Vinalopo de Elche, Alicante, Spain
:
Pulmonary Department, Hospital Dr Peset, Valencia, Spain
Ros JA:
Pulmonary Department, Hospital Virgen de la Arrixaca, Murcia, Spain
:
Pulmonary Department, Hospital Arnau de Vilanova, Valencia, Spain
Rodriguez-Portal JA:
Pulmonary Department, Hospital Virgen del Rocio, Seville, Spain
Andreu AL:
Pulmonary Department, Hospital los Arcos, Murcia, Spain
:
Pulmonary Department, Hospital General, Castellon, Spain
Rodriguez-Hermosa JL:
Pulmonary Department, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain
Gonzalez-Villaescusa C:
Pulmonary Department, Hospital Clinico, INCLIVA, Valencia, Spain
Soriano JB:
Pulmonary Department, Hospital La Princesa, Universidad Autónoma, Madrid, Spain
Signes-Costa J:
Pulmonary Department, Hospital Clinico, INCLIVA, Valencia, Spain.
Green Published, gold
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