Prenatal and child vitamin D levels and allergy and asthma in childhood
Por:
Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, Garcia-Aymerich J, Guxens M, Irizar A, Júlvez J, Luque-García L, Rodríguez-Dehli AC, Tardón A, Torrent M, Vioque J, Vrijheid M and Casas M
Publicada:
1 may 2023
Ahead of Print:
1 sep 2022
Resumen:
Background Early-life vitamin D deficiency may impair immune system development contributing to allergy and asthma onset. Findings from prospective studies are inconsistent. Objective To examine whether maternal and child vitamin D levels are associated with allergic and asthma-related symptoms throughout childhood in a Spanish birth cohort. Methods 25-Hydroxyvitamin D-3 (25(OH)D-3) levels were measured in the serum of pregnant women (N = 2525) and children (N = 803). Information on allergic and asthma-related symptoms was obtained from repeated questionnaires from 1 to 9 years. Results A total of 19% of mothers and 24% of children had deficient 25(OH)D-3 levels (<20 ng/ml). Higher child 25(OH)D-3 levels at 4 years were associated with lower odds of atopic eczema from 4 to 9 years (adjusted odds ratio = 0.90; 95% CI = 0.84-0.97 per 5 ng/ml). Higher maternal and child 25(OH)D-3 levels were associated with a lower prevalence of late-onset wheezing at the limit of statistical significance (adjusted relative risk ratio (RRRadj) = 0.86; 95% CI = 0.74-1.00 and RRRadj = 0.76; 95% CI = 0.58-1.02 per 5 ng/ml, respectively). All the remaining associations were null. Conclusion Child 25(OH)D-3 levels at pre-school age are associated with a reduced odds of atopic eczema in later childhood and both maternal and child levels may reduce the prevalence of late-onset wheezing. Impact In this Spanish birth cohort, with a total of 19% of mothers and 24% of children with deficient levels of vitamin D, higher child vitamin D at 4 years of age was associated with reduced odds of atopic eczema up to 9 years. There was also some evidence that higher maternal and child vitamin D levels reduced the prevalence of late-onset wheezing. Although these findings need replication, they may imply optimal vitamin D levels at pre-school age to prevent atopic eczema.
Filiaciones:
Sangüesa J:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Sunyer J:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Garcia-Esteban R:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Abellan A:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain
:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Facultat d'Infermeria i Podologia, Universitat de València, Valencia, Spain
Unidad Mixta de Investigación en Epidemiología y Salud Ambiental, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain
Garcia-Aymerich J:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Guxens M:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
Irizar A:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Public Health Department of Gipuzkoa, San Sebastián, Spain
Health Research Institute BIODONOSTIA, San Sebastián, Spain
Júlvez J:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Pere Virgili Health Research Institute (IISPV), Hospital Universitari Sant Joan de Reus, Reus (Tarragona), Spain
Luque-García L:
Department of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, 48940, Spain
Rodríguez-Dehli AC:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Hospital San Agustín, Servicio de Salud del Principado de Asturias (SESPA), Avilés, Asturias, Spain
Tardón A:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
IUOPA, University of Oviedo, Health Research Institute of Asturias, ISPA, Asturias, Spain
Torrent M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Area de Salud de Menorca, IB-SALUT, Menorca, Spain
Vioque J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Institute for Health and Biomedical Research ISABIAL-UMH, Alicante, Spain
Nutritional Epidemiology Unit, University Miguel Hernandez, Elche-Alicante, Spain
Vrijheid M:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Casas M:
ISGlobal, Barcelona, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
|