Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS-CoV-2 Positive Mothers
Por:
Arias-Borrego A, Soto Cruz FJ, Selma-Royo M, Bäuerl C, García Verdevio E, Pérez-Cano FJ, Lerin C, Velasco López I, Martínez-Costa C, Collado MC and García-Barrera T
Publicada:
1 ago 2022
Ahead of Print:
1 jun 2022
Resumen:
Scope Lack of information about the impact of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the elemental and metabolomic profile of human milk (HM). Methods and results An observational study on HM from mothers with COVID-19 is conducted including a prepandemic control group. Maternal-infant clinical records and symptomatology are recorded. The absolute quantification of elements and untargeted relative metabolomic profiles are determined by inductively coupled plasma mass spectrometry and gas chromatography coupled to mass spectrometry, respectively. Associations of HM SARS-CoV-2 antibodies with elemental and metabolomic profiles are studied. COVID-19 has a significant impact on HM composition. COVID-19 reduces the concentrations of Fe, Cu, Se, Ni, V, and Aluminium (Al) and increases Zn compared to prepandemic control samples. A total of 18 individual metabolites including amino acids, peptides, fatty acids and conjugates, purines and derivatives, alcohols, and polyols are significantly different in HM from SARS-CoV-2 positive mothers. Aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine, and linoleic acid pathways are significantly altered. Differences are obtained depending on COVID-19 symptomatic and asymptomatic status. Conclusions This study provides unique insights about the impact of maternal SARS-CoV-2 infection on the elemental and metabolomic profiles of HM that warrants further research due the potential implications for infant health.
Filiaciones:
Arias-Borrego A:
Research Center for Natural Resources, Health and the Environment (RENSMA), Department of Chemistry, Faculty of Experimental Sciences. Fuerzas Armadas Ave, University of Huelva, Huelva, 21007, Spain
Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, Professor García González Ave., Seville, 41012, Spain
Soto Cruz FJ:
Research Center for Natural Resources, Health and the Environment (RENSMA), Department of Chemistry, Faculty of Experimental Sciences. Fuerzas Armadas Ave, University of Huelva, Huelva, 21007, Spain
Selma-Royo M:
Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Agustin Escardino 7, 46980 Paterna, Valencia, Spain
Bäuerl C:
Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Agustin Escardino 7, 46980 Paterna, Valencia, Spain
:
Department of Gynecology and Obstetrics, Hospital Universitario Doctor Peset, Valencia, 46017, Spain
Pérez-Cano FJ:
Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), Barcelona, 08028, Spain
Nutrition and Food Safety Research Institute (INSA-UB), Santa Coloma de Gramenet, 08921, Spain
Lerin C:
Endocrinology Department, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, 08950, Spain
Velasco López I:
Department of Gynecology & Obstetrics, Hospital Universitari Germans Trias i Pujol, s/n Carretera del Canyet, Badalona, 08916, Spain
Martínez-Costa C:
Department of Pediatrics, University of Valencia., INCLIVA Biomedical Research Institute, Avenida Blasco Ibáñez 15-17, Valencia, 46010, Spain
Collado MC:
Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Agustin Escardino 7, 46980 Paterna, Valencia, Spain
García-Barrera T:
Research Center for Natural Resources, Health and the Environment (RENSMA), Department of Chemistry, Faculty of Experimental Sciences. Fuerzas Armadas Ave, University of Huelva, Huelva, 21007, Spain
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