Maternal occupational exposure to chemicals and child cognitive function
Por:
Ish J, Symanski E, Gimeno Ruiz de Porras D, Casas M, Delclos GL, Guxens M, Ibarluzea JM, Iñiguez C, Lertxundi A, Rebagliato M, Swartz MD and Whitworth KW
Publicada:
1 oct 2022
Ahead of Print:
1 may 2022
Categoría:
Pediatrics, perinatology and child health
Resumen:
Background Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine-disrupting chemicals (EDCs). Methods We included 1058 mother-child pairs from the INfancia y Medio Ambiente (INMA) project (2003-2008). Using a job-exposure matrix, exposure probability scores for ten EDC groups were assigned to each mother based on her longest held job during pregnancy. At the child's 5-year visit, the McCarthy Scales of Children's Abilities was administered, yielding the general cognitive index and scales for specific cognitive domains. We analyzed region-specific associations between EDC exposures and each outcome separately using adjusted linear regression and combined region-specific effect estimates using random-effects meta-analyses. Results Approximately 39% of women were exposed to at least one EDC group, but exposure to most individual EDC groups was low (<5%). Maternal organic solvent exposure was associated with lower quantitative scores among children (-5.8 points, 95% confidence interval: -11.0, -0.5). Though statistically non-significant, exposures to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds, and miscellaneous chemicals were associated with poorer offspring performance for most or all cognitive domains. Conclusions This study found limited evidence for a role of maternal occupational EDC exposures on child cognition. Further research is needed to better characterize exposures among pregnant workers. Impact Using data from a prospective birth cohort, we help fill an important research gap regarding the potential consequences of work-related exposure to endocrine-disrupting chemicals (EDCs) among pregnant women on child neurodevelopment. We expand on existing literature-largely limited to pesticide and organic solvent exposures-by using a job-exposure matrix to estimate exposure to several EDC groups. We found limited evidence of an association between maternal occupational EDC exposure and children's overall cognition. We did observe specific associations between exposure to organic solvents and lower quantitative reasoning scores.
Filiaciones:
Ish J:
Southwest Center for Occupational and Environmental Health (SWCOEH), Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health in San Antonio, San Antonio, TX, USA
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Symanski E:
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA
Gimeno Ruiz de Porras D:
Southwest Center for Occupational and Environmental Health (SWCOEH), Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health in San Antonio, San Antonio, TX, USA
CIBER Epidemiología y Salud Pública, Madrid, Spain
Center for Research in Occupational Health (CiSAL), Universitat Pompeu Fabra, Barcelona, Spain
Casas M:
CIBER Epidemiología y Salud Pública, Madrid, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
Delclos GL:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Center for Research in Occupational Health (CiSAL), Universitat Pompeu Fabra, Barcelona, Spain
Southwest Center for Occupational and Environmental Health (SWCOEH), Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA
Guxens M:
CIBER Epidemiología y Salud Pública, Madrid, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra, Barcelona, Spain
Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
Ibarluzea JM:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Biodonostia, Environmental Epidemiology and Child Development Group, San Sebastian, Spain
Health Department of the Basque Government, Sub-directorate of Public Health of Gipuzkoa, San Sebastian, Spain
:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Department of Statistics and Operational Research, Universitat de València, València, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I Universitat de València, València, Spain
Lertxundi A:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Biodonostia, Environmental Epidemiology and Child Development Group, San Sebastian, Spain
Department of Preventive Medicine and Public Health, University of the Basque Country (UPV-EHU), Leioa, Spain
:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I Universitat de València, València, Spain
Unit of Medicine, Universitat Jaume I, Castellón de la Plana, Spain
Swartz MD:
Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, USA
Whitworth KW:
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Green Accepted
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