Parkinson's Disease Motor Subtypes Change with the Progression of the Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up
Por:
Santos García D, Canfield H, de Deus Fonticoba T, Cores Bartolomé C, Naya Ríos L, García Roca L, Martínez Miró C, Jesús S, Aguilar M, Pastor P, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Blázquez Estrada M, Seijo M, Rúiz Martínez J, Valero C, Kurtis M, de Fábregues O, González Ardura J, Alonso Redondo R, Ordás C, López Díaz LM, McAfee D, Martinez-Martin P, Mir P and COPPADIS Study Group
Publicada:
1 ene 2022
Resumen:
Background: Motor phenotype (MP) can be associated with a different prognosis in Parkinson's disease (PD), but it is not fixed and can change over time.
Objective: Our aim was to analyze how the MP changed over time and to identify factors associated with the changes in PD patients from a multicenter Spanish PD cohort.
Methods: PD patients who were recruited from January-2016 to November-2017 (baseline visit; V0) and evaluated again at a 2-year +/- 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this study. MP was calculated at both visits based on Jankovic classification in TD (tremor dominant), IND (indeterminate), or PIGD (postural instability and gait difficulty). Sociodemographic and clinical data were collected, including serum biomarkers.
Results: Five hundred eleven patients (62.57 +/- 8.59 years old; 59.2% males) were included in the study. At V0, MP was: 47.4% (242/511) TD; 36.6% (187/511) PIGD; 16% (82/511) IND. Up to 38% (194/511) of the patients changed their phenotype from V0 to V2, being the most frequent from TD to IND (8.4%) and from TD to PIGD (6.7%). A worse cognitive status (OR = 0.966) and less autonomy for activities of daily living (OR = 0.937) at V0 and a greater increase in the globalNMS burden (OR = 1.011) from V0 to V2 were associated with changing from TD to another phenotype after 2-year follow-up.
Conclusion: The MP in PD can change over time. With disease progression, the percentage of cases with non-tremoric MP increases. PD patients who changed from TD to postural instability and gait difficulty increased NMS burden significantly.
Filiaciones:
Santos García D:
Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain
Canfield H:
Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain
de Deus Fonticoba T:
Complejo Hospitalario Universitario de Ferrol (CHUF), A Coruña, Spain
Cores Bartolomé C:
Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain
Naya Ríos L:
Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain
García Roca L:
Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain
Martínez Miró C:
Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain
Jesús S:
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Spain
Aguilar M:
Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain
Pastor P:
Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain
Cosgaya M:
Hospital Clinic de Barcelona, Barcelona, Spain
García Caldentey J:
Centro Neurológico Oms 42, Palma de Mallorca, Spain
Caballol N:
Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain
Legarda I:
Hospital Universitario Son Espases, Palma de Mallorca, Spain
Hernández Vara J:
Hospital Universitario Vall d'Hebron, Barcelona, Spain
Cabo I:
Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain
López Manzanares L:
Hospital Universitario La Princesa, Madrid, Spain
González Aramburu I:
Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Spain
Hospital Universitario Marqués de Valdecilla, Santander, Spain
Ávila Rivera MA:
Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Barcelona, Spain
Gómez Mayordomo V:
Hospital Universitario Clínico San Carlos, Madrid, Spain
Nogueira V:
Hospital Da Costa, Burela, Lugo, Spain
Puente V:
Hospital del Mar, Barcelona, Spain
Dotor J:
Hospital Universitario Virgen Macarena, Sevilla, Spain
Borrué C:
Hospital Infanta Sofía, Madrid, Spain
Solano Vila B:
Institut d'Assistència Sanitària (IAS) - Institut Català de la Salut, Girona, Spain
:
Hospital General Universitario de Elche, Elche, Spain
Vela L:
Fundación Hospital de Alcorcón, Madrid, Spain
Escalante S:
Fundación Hospital de Alcorcón, Madrid, Spain
Cubo E:
Complejo Asistencial Universitario de Burgos, Burgos, Spain
Carrillo Padilla F:
Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain
Martínez Castrillo JC:
Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
Sánchez Alonso P:
Hospital Universitario Puerta de Hierro, Madrid, Spain
Alonso Losada MG:
Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain
López Ariztegui N:
Complejo Hospitalario de Toledo, Toledo, Spain
Gastón I:
Complejo Hospitalario de Navarra, Pamplona, Spain
Kulisevsky J:
Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Spain
Hospital de Sant Pau, Barcelona, Spain
Blázquez Estrada M:
Hospital Universitario Central de Asturias, Oviedo, Spain
Seijo M:
Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain
Rúiz Martínez J:
Hospital Universitario Donostia, San Sebastián, Spain
:
Hospital Arnau de Vilanova, Valencia, Spain
Kurtis M:
Hospital Ruber Internacional, Madrid, Spain
de Fábregues O:
Hospital Universitario Vall d'Hebron, Barcelona, Spain
González Ardura J:
Hospital de Cabueñes, Gijón
Alonso Redondo R:
Universitario Lucus Augusti (HULA), Lugo, Spain
Ordás C:
Hospital Rey Juan Carlos, Madrid, Spain, Madrid, Spain
López Díaz LM:
Complejo Hospitalario Universitario de Orense (CHUO), Orense, Spain
McAfee D:
Univeristy of Maryland School of Medicine, Baltimore, MD, USA
Martinez-Martin P:
Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Spain
Mir P:
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Spain
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