Maternal occupational exposures and fetal growth in a Spanish birth cohort
Por:
Ish J, Gimeno Ruiz de Porras D, Symanski E, Ballester F, Casas M, Delclos GL, Guxens M, Ibarluzea J, Iñiguez C, Santa-Marina L, Swartz MD and Whitworth KW
Publicada:
1 ene 2022
Ahead of Print:
7 abr 2022
Categoría:
Multidisciplinary
Resumen:
While the epidemiologic literature suggests certain maternal occupational exposures may be associated with reduced measures of size at birth, the occupational literature employing fetal biometry data to assess fetal growth is sparse. The present study examines associations between maternal occupational exposures and ultrasound-measured fetal growth. We included 1,739 singleton pregnancies from the INfancia y Medio Ambiente (INMA) project (2003-2008). At 32 weeks of pregnancy, interviewers ascertained mothers' employment status and assessed job-related physical loads, work schedules, and job strain during pregnancy. Job titles were linked to a job-exposure matrix to estimate exposure to 10 endocrine disrupting chemical (EDC) groups. We calculated z-scores from longitudinal growth curves representing trajectories from 0-12, 12-20 and 20-34 gestational weeks for abdominal circumference (AC), biparietal diameter (BPD), femur length (FL), and estimated fetal weight (EFW). Linear mixed models clustered by IMNA region (i.e., Gipuzkoa, Sabadell, Valencia) were used to examine associations between occupational exposures and fetal growth. Effect estimates are presented as percentage change in fetal growth. There was limited evidence of associations between work-related non-chemical stressors and fetal growth. We observed associations of similar magnitude between multiple EDC groups and decreased EFW trajectories during 20-34 gestational weeks (phthalates: -1.4% [-3.5, 0.6%]; alkylphenolic compounds (APCs): -1.1% [-2.3, 0.1%]; miscellaneous chemicals: -1.5% [-3.7, 0.8%]), while miscellaneous chemicals were associated with increased BPD from 12-20 weeks (2.1% [0.8, 3.5%]). Notably, 67% of women exposed to phthalates were hairdressers; 68% of women exposed to APCs worked as domestic cleaners. In conclusion, we found limited evidence that maternal occupational exposures impact fetal growth. Further research should consider the combined impact of multiple workplace exposures.
Filiaciones:
Ish J:
Southwest Center for Occupational and Environmental Health (SWCOEH), Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health in San Antonio, San Antonio, TX, United States of America
Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America
Gimeno Ruiz de Porras D:
Southwest Center for Occupational and Environmental Health (SWCOEH), Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health in San Antonio, San Antonio, TX, United States of America
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, United States of America
CIBER Epidemiología y Salud Pública, Madrid, Spain
Symanski E:
Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, United States of America
:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Department of Nursing, Universitat de València, Valencia, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I Universitat de València, València, Spain
Casas M:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Universitat Pompeu Fabra, Barcelona, Spain
ISGlobal, Barcelona, Spain
Delclos GL:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Center for Research in Occupational Health (CiSAL), Universitat Pompeu Fabra, Barcelona, Spain
Southwest Center for Occupational and Environmental Health (SWCOEH), Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, United States of America
Guxens M:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Universitat Pompeu Fabra, Barcelona, Spain
ISGlobal, Barcelona, Spain
Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
Ibarluzea J:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Environmental Epidemiology and Child Development Group, Biodonostia, San Sebastian, Spain
Health Department of the Basque Government, Sub-directorate of Public Health of Gipuzkoa, San Sebastian, Spain
Faculty of Psychology, Universidad del País Vasco (UPV/EHU), San Sebastian, Spain
:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I Universitat de València, València, Spain
Department of Statistics and Operational Research, Universitat de València, València, Spain
Santa-Marina L:
CIBER Epidemiología y Salud Pública, Madrid, Spain
Environmental Epidemiology and Child Development Group, Biodonostia, San Sebastian, Spain
Health Department of the Basque Government, Sub-directorate of Public Health of Gipuzkoa, San Sebastian, Spain
Swartz MD:
Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, United States of America
Whitworth KW:
Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America
Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, United States of America
gold, Green Published
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