From the smallest to the largest subcellular plant pathogen: Citrus tristeza virus and its unique p23 protein
Por:
Moreno P, López C, Ruiz-Ruiz S, Peña L and Guerri J
Publicada:
1 jun 2022
Ahead of Print:
1 mar 2022
Resumen:
Knowledge on diseases caused by Citrus tristeza virus (CTV) has greatly increased in last decades after their etiology was demonstrated in the past seventies. Professor Ricardo Flores substantially contributed to these advances in topics like: i) improvement of virus purification to obtain biologically active virions, ii) sequencing mild CTV isolates for genetic comparisons with sequences of moderate or severe isolates and genetic engineering, iii) analysis of genetic variation of both CTV genomic RNA ends and features of the highly variable 5' end that allow accommodating this variation within a conserved secondary structure, iv) studies on the structure, sub cellular localization and biological functions of the CTV-unique p23 protein, and v) potential use of p23 and other 3'-proximal regions of the CTV genome to develop transgenic citrus resistant to the virus. Here we review his main achievements on these topics and how they contributed to deeper understanding of CTV biology and to new potential measures for disease control.
Filiaciones:
Moreno P:
Instituto Valenciano de Investigaciones Agrarias (IVIA), Moncada, 46113-Valencia, Spain. (Retired)
López C:
Instituto de Conservación y Mejora de la Agrodiversidad Valenciana (COMAV), Universitat Politècnica de València, 46022-Valencia, Spain
:
Unidad Mixta de Investigación en Genómica y Salud, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), 46022-Valencia, Spain
Peña L:
Instituto de Biología Molecular y Celular de Plantas (IBMCP). Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Politécnica de Valencia (UPV), 46022-Valencia, Spain
Guerri J:
Instituto Valenciano de Investigaciones Agrarias (IVIA), Moncada, 46113-Valencia, Spain. (Retired)
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