Plasma Aromatase Activity Index, Gonadotropins and Estrone Are Associated with Frailty Syndrome in Post-Menopausal Women with Breast Cancer
Por:
García-Sánchez J, Mafla-España MA, Tejedor-Cabrera C, Avellán-Castillo O, Torregrosa MD and Cauli O
Publicada:
1 mar 2022
Ahead of Print:
7 mar 2022
Categoría:
Oncology
Resumen:
Frailty syndrome is associated with poor outcomes, morbidity and premature mortality. We performed a cross-sectional study to evaluate the presence of frailty syndrome based on Fried's frailty phenotype in post-menopausal women with breast cancer. We further analyzed the association between frailty syndrome with geriatric assessments and the association with the concentration of gonadotropins LH and FSH, estrogens, androgens and the aromatase activity index in the blood. We enrolled 47 post-menopausal women with localized breast cancer (mean age 66.8 +/- 1.3 years (range 52-83)) prior to the starting of adjuvant endocrine therapy. Patients were identified as "non-frail" (robust) or "prefrail/frail" if they fulfilled at least one frailty criteria. In order to determine associations among variables and to control for other variables potentially affecting frailty syndrome (age, comorbidity index and previous chemotherapy treatment), we performed a logistic regression analysis. The receiver operating characteristic curve was performed to assess the sensitivity and specificity of the hormonal concentration to discriminate prefrail/frail versus non-frail individuals. Significant positive associations were observed between the severity of frailty syndrome and estrone, FSH and LH concentrations and the aromatase activity index in the blood (p < 0.05). Further research into the role of hormonal biomarkers should be evaluated in follow-up studies in order to recommend their use as suitable biomarkers of frailty syndrome in breast cancer patients.
Filiaciones:
:
Medical Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain
Medical Oncology Department, Hospital Center of Wallonie Picardy, 7500 Tournai, Belgium
Mafla-España MA:
Frailty Research Organized Group, University of Valencia, 46010 Valencia, Spain
Department of Nursing, University of Valencia, 46010 Valencia, Spain
Tejedor-Cabrera C:
Department of Nursing, University of Valencia, 46010 Valencia, Spain
Avellán-Castillo O:
Department of Nursing, University of Valencia, 46010 Valencia, Spain
:
Medical Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain
Cauli O:
Frailty Research Organized Group, University of Valencia, 46010 Valencia, Spain
Department of Nursing, University of Valencia, 46010 Valencia, Spain
Green Published, gold
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