The Response to Biologics is Better in Patients with Severe Asthma Than in Patients with Asthma-COPD Overlap Syndrome
Por:
Pérez de Llano L, Dacal Rivas D, Marina Malanda N, Plaza Moral V, Gullón Blanco JA, Muñoz-Esquerre M, García-Moguel I, Díaz Campos RM, Martínez-Moragón E, Harbenau Mena A, Cosío BG, Padilla Galo A and Cisneros Serrano C
Publicada:
1 ene 2022
Ahead of Print:
18 mar 2022
Resumen:
Although biologics have demonstrated to be effective in T2-high asthma patients, there is little experience with these drugs in asthma-COPD overlap (ACO). The aim of this study was to compare the effectiveness of biologics in these two conditions. We included 318 patients (24 ACO and 297 asthma) treated with monoclonal antibodies and followed for at least 12 months Omalizumab was the most frequently employed biologic agent both in patients with ACO and asthma. Asthma control test (ACT) scores after at least 12 months of biologic therapy were not significantly different between groups. The percentage of patients with >= 1 exacerbation and >= 1 corticosteroid burst was significantly higher in ACO patients (70.8 vs 27.3 and 83.3% vs 37.5%, respectively), whereas the percentage of "controlled" patients (with no exacerbations, no need for corticosteroids and ACT >= 20) was significantly lower (16.7% vs 39.7%). In conclusion, this report suggests that patients with ACO treated with biologics reach worse outcomes than asthma patients.
Filiaciones:
Pérez de Llano L:
Pneumology Service, Hospital Lucus Augusti, EOXI Lugo, Cervo e Monforte, Lugo, Spain
Dacal Rivas D:
Pneumology Service, Hospital Lucus Augusti, EOXI Lugo, Cervo e Monforte, Lugo, Spain
Marina Malanda N:
Pneumology Service, Hospital Universitario de Cruces, Barakaldo, Bizkaia, Spain
Plaza Moral V:
Pneumology Service, Hospital Sta Creu i Sant Pau, Barcelona, Spain
Gullón Blanco JA:
Pneumology Service, University Hospital San Agustín, Avilés, Spain
Muñoz-Esquerre M:
Pneumology Service, Hospital Bellvitge-IDIBELL, Barcelona, Spain
García-Moguel I:
Allergy Service, Hospital 12 de Octubre, Madrid, Spain
Díaz Campos RM:
Pneumology Service, Institute for Health Research (i+12), Hospital Universitario 12 de Octubre, Madrid, Spain
:
Pneumology Service, Hospital Doctor Peset, Valencia, Spain
Harbenau Mena A:
Allergy Service, Hospital de Mérida, Badajoz, Spain
Cosío BG:
Pneumology Service, Hospital Universitario Son Espases-IdISBa-CIBERES, Palma de Mallorca, Spain
Padilla Galo A:
Pneumology Service, Hospital Costa del Sol, Marbella, Málaga, Spain
Cisneros Serrano C:
Pneumology Service, Hospital Universitario de La Princesa, Madrid, Spain
Green Published, gold
|