Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
Por:
Manzano, M, Talavera-Rodriguez, A, Moreno, E, Madrid, N, Gosalbes, M, Ron, R, Dronda, F, Perez-Molina, J, Lanza, V, Diaz, J, Moreno, S, Navia, B and Serrano-Villar, S
Publicada:
1 mar 2022
Ahead of Print:
14 mar 2022
Resumen:
While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.
Filiaciones:
Department of Nutrition and Food Science, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, Spain.; Department of Infectious Diseases, Hospital Universitario Ramon y Cajal and IRYCIS, 28034 Madrid, Spain.; CIBERINFEC, Instituto de Salud Carlos III, 28029 Madrid, Spain.; FISABIO-Salud Publica, 46020 Valencia, Spain.; CIBERESP, Instituto de Salud Carlos III, 28029, Madrid, Spain.; Bioinformatics Unit, Hospital Universitario Ramon y Cajal and IRYCIS, 28034 Madrid, Spain.; Resear
gold, Green Published, Green Accepted
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