ORAL MELANOMA WITH OSTEOCARTILAGINEOUS DIFFERENTIATION: A CASE REPORT AND LITERATURE REVIEW
Por:
Pallotta, M, Beltramini, G, Moneghini, L, Monteverdi, R, Gianni, A, Silvestre, F and Baj, A
Publicada:
1 abr 2017
Resumen:
Osteocartilagineous differentiation within malignant melanoma is a rare occurrence with several implications for diagnosis. Most of the reported cases have occurred in acral lentiginous malignant melanomas. In this paper, the authors describe the clinical, morphological, immunohistochemical features and surgical treatment of a case of primary oral mucosal melanoma with osteocartilaginous differentiation and they review the existing literature. The clinical history of a 67-year-old man affected of oral malignant melanoma was described from the first presentation to the second recurrence. FISH analysis on primary lesion and on relapses showed positive results both in epithelioid and in osteocondroblastic areas. Because of the scarcity of literature in osteogenic melanoma, histological identification may be problematic and prognostic factors and therapeutic protocols are nor well established. Immunohistochemical and molecular techniques can help to diagnosis this rare lesion.
Filiaciones:
Pallotta, M:
Osped Maggiore Policlin Milano, Fdn IRCCS Ca Granda, Maxillofacial & Dent Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
Beltramini, G:
Osped Maggiore Policlin Milano, Fdn IRCCS Ca Granda, Maxillofacial & Dent Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
Moneghini, L:
Univ Milan, Azienda Osped Santi Paolo & Carlo, Dept Pathol, Milan, Italy
Monteverdi, R:
Ist Ortoped Galeazzi Milan, IRCCS, Dept Maxillofacial Surg, Milan, Italy
Gianni, A:
Osped Maggiore Policlin Milano, Fdn IRCCS Ca Granda, Maxillofacial & Dent Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
:
Univ Valencia, Dr Peset Univ Hosp, Dept Stomatol, Stomatol & Oral Surg, Valencia, Spain
Baj, A:
Osped Maggiore Policlin Milano, Fdn IRCCS Ca Granda, Maxillofacial & Dent Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
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