Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
Por:
Tahaei H, Gignac F, Pinar A, Fernandez-Barrés S, Romaguera D, Vioque J, Santa-Marina L, Subiza-Pérez M, Llop S, Soler-Blasco R, Arija V, Salas-Salvadó J, Tardón A, Riaño-Galán I, Sunyer J, Guxens M and Julvez J
Publicada:
1 feb 2022
Ahead of Print:
25 ene 2022
Resumen:
Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: -22.95, -0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.
Filiaciones:
Tahaei H:
ISGlobal, 08003 Barcelona, Spain
Gignac F:
ISGlobal, 08003 Barcelona, Spain
Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
Pinar A:
ISGlobal, 08003 Barcelona, Spain
Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, 43204 Reus, Spain
Fernandez-Barrés S:
ISGlobal, 08003 Barcelona, Spain
Romaguera D:
ISGlobal, 08003 Barcelona, Spain
Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
Vioque J:
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), 46020 Alicante, Spain
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Santa-Marina L:
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, 20013 San Sebastian, Spain
Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, 20014 San Sebastian, Spain
Subiza-Pérez M:
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, 20014 San Sebastian, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, 46020 Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, 46020 Valencia, Spain
Arija V:
Universitat Rovira i Virgili (URV), Nutrition and Mental Health Research Group (NUTRISAM), 43201 Reus, Spain
Salas-Salvadó J:
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, 43204 Reus, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
Universitat Rovira i Virgili (URV), Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, 43201 Reus, Spain
Tardón A:
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
IUOPA-ISPA, Avda. Hospital Universitario s/n, 33011 Oviedo, Spain
Riaño-Galán I:
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
IUOPA-ISPA, Avda. Hospital Universitario s/n, 33011 Oviedo, Spain
Servicio de Pediatría, Endocrinología Pediátrica, HUCA, Roma Avenue S/n, 33001 Oviedo, Spain
Sunyer J:
ISGlobal, 08003 Barcelona, Spain
Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Guxens M:
ISGlobal, 08003 Barcelona, Spain
Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre, 3015 CN Rotterdam, The Netherlands
Julvez J:
ISGlobal, 08003 Barcelona, Spain
Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, 43204 Reus, Spain
Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Green Published, gold
|