Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans
Por:
Mayneris-Perxachs J, Castells-Nobau A, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Martínez-Hernández F, Burokas A, Coll C, Moreno-Navarrete JM, Zapata-Tona C, Pedraza S, Pérez-Brocal V, Ramió-Torrentà L, Ricart W, Moya A, Martínez-García M, Maldonado R and Fernández-Real JM
Publicada:
9 mar 2022
Ahead of Print:
1 mar 2022
Resumen:
Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant life entities on the planet, are a commonly overlooked component of the gut virome, dominated by the Caudovirales and Microviridae bacteriophages. Here, we show in a discovery (n = 114) and a validation cohort (n = 942) that subjects with increased Caudovirales and Siphoviridae levels in the gut microbiome had better performance in executive processes and verbal memory. Conversely, increased Microviridae levels were linked to a greater impairment in executive abilities. Microbiota transplantation from human donors with increased specific Caudovirales (>90% from the Siphoviridae family) levels led to increased scores in the novel object recognition test in mice and up-regulated memory-promoting immediate early genes in the prefrontal cortex. Supplementation of the Drosophila diet with the 936 group of lactococcal Siphoviridae bacteriophages resulted in increased memory scores and upregulation of memory-involved brain genes. Thus, bacteriophages warrant consideration as novel actors in the microbiome-brain axis.
Filiaciones:
Mayneris-Perxachs J:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Castells-Nobau A:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Arnoriaga-Rodríguez M:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Garre-Olmo J:
Research Group on Aging, Disability, and Health, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Serra-Hunter Fellow. Department of Nursing, University of Girona, Girona, Spain
Puig J:
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Institute of Diagnostic Imaging (IDI)-Research Unit (IDIR), Parc Sanitari Pere Virgili, Barcelona, Spain
Medical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Department of Radiology (IDI), Dr. Josep Trueta University Hospital, Girona, Spain
Ramos R:
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Vascular Health Research Group of Girona (ISV-Girona), Jordi Gol Institute for Primary Care Research, (Institut Universitari per a la Recerca en Atenció Primària Jordi Gol I Gorina-IDIAPJGol), Girona Biomedical Research Institute, (IDIBGI), Dr. Josep Trueta University Hospital, Catalonia, Spain
Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta University Hospital, Catalonia, Spain
Martínez-Hernández F:
Department of Physiology, Genetics, and Microbiology, University of Alicante, Alicante, Spain
Burokas A:
Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania
Coll C:
Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Dr. Josep Trueta University Hospital, Girona, Spain
Moreno-Navarrete JM:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Zapata-Tona C:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Pedraza S:
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Medical Imaging, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Department of Radiology (IDI), Dr. Josep Trueta University Hospital, Girona, Spain
:
Area of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain
Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ramió-Torrentà L:
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Dr. Josep Trueta University Hospital, Girona, Spain
Neurodegeneration and Neuroinflammation research group. Girona Biomedical Research Institute (IdibGi), Girona, Spain
Ricart W:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
:
Area of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain
Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Madrid, Spain
Institute for Integrative Systems Biology (I2SysBio), University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain
Martínez-García M:
Department of Physiology, Genetics, and Microbiology, University of Alicante, Alicante, Spain
Maldonado R:
Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
Fernández-Real JM:
Department of Diabetes, Endocrinology, and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain
Nutrition, Eumetabolism, and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain
Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain
Green Published, hybrid
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