Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa
Por:
Presley, C, Valenciano, A, Fernandez-Murga, M, Du, Y, Shanaiah, N, Cassera, M, Goetz, M, Clement, J and Kingston, D
Publicada:
1 mar 2018
Resumen:
Nine new compounds containing either a chromane or chromene ring moiety were isolated from the monotypic plant Koeberlinia spinosa. Compounds 1-4 are chromanes with all possible E and Z isomers of the isoprenoid side chain, with compound 5 a methylated derivative of 1. Compounds 6 and 7 were assigned as diastereomeric cyclized derivatives of 2 and were probably artifacts formed during the extraction or the isolation processes. Compounds 8 and 9 were characterized as new chromenes. Structure elucidation of 1-9 was conducted via 1D and 2D NMR spectroscopic data interpretation, and absolute configurations were determined by ECD spectroscopic analysis. Compounds 2, 5, 6, and 7 had weak antiplasmodial activity, while none of the compounds exhibited antiproliferative activity. The isolation, structure elucidation, and biological evaluation of these compounds are presented.
Filiaciones:
Presley, C:
Virginia Tech, Dept Chem, M-C 0308, Blacksburg, VA 24061 USA
Valenciano, A:
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
Univ Georgia, CTEGD, Athens, GA 30602 USA
:
Virginia Tech, Dept Biochem, M-C 0308, Blacksburg, VA 24061 USA
Du, Y:
Virginia Tech, Dept Chem, M-C 0308, Blacksburg, VA 24061 USA
Shanaiah, N:
Virginia Tech, Dept Chem, M-C 0308, Blacksburg, VA 24061 USA
Cassera, M:
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
Univ Georgia, CTEGD, Athens, GA 30602 USA
Goetz, M:
Nat Prod Discovery Inst, 3805 Old Easton Rd, Doylestown, PA 18902 USA
Clement, J:
Nat Prod Discovery Inst, 3805 Old Easton Rd, Doylestown, PA 18902 USA
Kingston, D:
Virginia Tech, Dept Chem, M-C 0308, Blacksburg, VA 24061 USA
Virginia Tech, Ctr Drug Discovery, M-C 0308, Blacksburg, VA 24061 USA
Green Accepted
|