Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp (Meliaceae) from Madagascar
Por:
Du, Y, Abedi, A, Valenciano, A, Fernandez-Murga, M, Cassera, M, Rasamison, V, Applequist, W, Miller, J and Kingston, D
Publicada:
1 dic 2017
Resumen:
An extract of Malleastrum sp. (Meliaceae) collected in Madagascar by the Madagascar International Cooperative Biodiversity Group was found to have antimalarial activity, with an IC50 value between 2.5 and 5gml(-1). After purification by liquid-liquid partition, chromatography on a Diaion open column, C18SPE and C-18 reversed phase HPLC, the new butanolide, malleastrumolide A, was isolated. The structure of malleastrumolide A was determined by mass spectrometry, NMR, and ECD. The double bond position was determined by cross-metathesis and mass spectrometry. The compound has antiproliferative activity against the A2780 ovarian cancer cell line with an IC50 value of 17.4m and antiplasmodial activity against the drug-resistant Dd2 strain of Plasmodium falciparum with an IC50 value of 2.74m.
Filiaciones:
Du, Y:
Virginia Tech, Dept Chem, M-C 0212, Blacksburg, VA 24061 USA
Virginia Tech, Ctr Drug Discovery, M-C 0212, Blacksburg, VA 24061 USA
Abedi, A:
Virginia Tech, Dept Chem, M-C 0212, Blacksburg, VA 24061 USA
Virginia Tech, Ctr Drug Discovery, M-C 0212, Blacksburg, VA 24061 USA
Valenciano, A:
Univ Georgia, Dept Biochem & Mol Biol, CTEGD, Athens, GA 30602 USA
:
Virginia Tech, Dept Biochem, M-C 0308, Blacksburg, VA 24061 USA
Virginia Tech, Ctr Drug Discovery, M-C 0308, Blacksburg, VA 24061 USA
Cassera, M:
Univ Georgia, Dept Biochem & Mol Biol, CTEGD, Athens, GA 30602 USA
Virginia Tech, Dept Biochem, M-C 0308, Blacksburg, VA 24061 USA
Virginia Tech, Ctr Drug Discovery, M-C 0308, Blacksburg, VA 24061 USA
Rasamison, V:
Ctr Natl Applicat Rech Pharmaceut, BP 702, Antananarivo 101, Madagascar
Applequist, W:
Missouri Bot Garden, POB 299, St Louis, MO 63166 USA
Miller, J:
Missouri Bot Garden, POB 299, St Louis, MO 63166 USA
Kingston, D:
Virginia Tech, Dept Chem, M-C 0212, Blacksburg, VA 24061 USA
Virginia Tech, Ctr Drug Discovery, M-C 0212, Blacksburg, VA 24061 USA
Green Accepted
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