Candidate Allergens for Inclusion in the Spanish Standard Series Based on Data from the Spanish Contact Dermatitis Registry
Por:
Hernandez-Fernandez, C, Mercader-Garcia, P, Salvador, J, Perez, J, Redondo, V, Miquel, F, de Frutos, F, Ortega, M, Fernandez, V, Arnau, A, Ninet, V, Perez, R, Sanchez, T, Nieto, M, Baldrich, E, Guijarro, S, Mendaza, F, Gonzalez, I, Serna, M, Garces, M, Descalzo, M, Doval, I and Hernando, L
Publicada:
1 oct 2021
Ahead of Print:
1 oct 2021
Resumen:
Background: Standard patch test series must be updated using objective data on allergen sensitization. The Spanish standard series was last updated in 2016 and the European series in 2019, and the inclusion of several emerging allergens needs to be evaluated.
Material and methods: We conducted a prospective, observational, multicenter study of consecutive patients from the registry of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) who were patch tested in 2019 and 2020 with linalool hydroperoxide, limonene hydroperoxide, 2-hydroxyethyl-methacrylate, benzisothiazotinone, octylisothiazolinone, textile dye mix (TDM), sodium metabisulfite, propolis, bronopol, Compositae mix II, diazolidinyl urea, imidazolidinyl urea, decyl glucoside, and lauryl glucoside.
Results: We analyzed data for 4654 patients tested with diazolidinyl urea, imidazolidinyl urea, and bronopol, and 1890 tested with the other allergens. The values for the MOAHLFA index components were 30% for mate, 18% for occupational dermatitis, 15% for atopic dermatitis, 29% for hand, 6.5% for leg, 23% for face, and 68% for age > 40 years. Sensitization rates above 1% were observed for 7 allergens: linalool hydroperoxide, 2-hydroxyethyl-methacrylate, benzisothiazolinone, limonene hydroperoxide, TDM, sodium metabisulfite, and propolis. Three allergens had a current relevance rate of over 1%: linalool hydroperoxide, 2-hydroxyethyl-methacrylat, and limonene hydroperoxide. Benzisothiazotinone and TDM had a relevance rate of between 0.9% and 1%.
Conclusions: Our results indicate that 7 new allergens should be considered when extending the Spanish standard patch test series. The data from our series could be helpful for guiding the next extension of the European baseline series. (C) 2021 AEDV. Published by Elsevier Espana, S.L.U.
Filiaciones:
Hernandez-Fernandez, C:
Univ Las Palmas Gran Canaria, Hosp Univ Gran Canaria Doctor Negrin, Serv Dermatol, Las Palmas Gran Canaria, Spain
Mercader-Garcia, P:
Hosp Gen Univ Jose Ma Morales Meseguer, Serv Dermatol, Murcia, Spain
Salvador, J:
Hosp Gen Univ Alicante, Serv Dermatol, Alicante, Spain
Perez, J:
Hosp Univ La Princesa, Serv Dermatol, Madrid, Spain
Redondo, V:
Univ Santiago de Compostela, Complejo Hosp Univ Santiago, Serv Dermatol, Santiago De Compostela, Spain
:
Hosp Arnau Vilanova, Serv Dermatol, Valencia, Spain
de Frutos, F:
Hosp Univ 12 Octubre, Serv Dermatol, Madrid, Spain
Ortega, M:
Complejo Hosp Univ Toledo, Serv Dermatol, Toledo, Spain
Fernandez, V:
Hosp Badalona Germans Trias & Pujol, Serv Dermatol, Badalona, Spain
Arnau, A:
Hosp del Mar, Serv Dermatol, Inst Municipal Asistencia Sanitaria, Barcelona, Spain
Ninet, V:
Hosp Gen Univ Valencia, Serv Dermatol, Valencia, Spain
Perez, R:
Univ Basque Country, Hosp Univ Araba, Serv Dermatol, Vitoria, Spain
Sanchez, T:
Hosp Univ Infanta Sofia, Serv Dermatol, Madrid, Spain
Nieto, M:
Hosp Univ Guadalajara, Serv Dermatol, Guadalajara, Spain
Baldrich, E:
Hosp Santa Creu & Sant Pau, Serv Dermatol, Barcelona, Spain
Guijarro, S:
Hosp Univ Fuenlabrada, Serv Dermatol, Madrid, Spain
Mendaza, F:
Hosp Univ Fdn Jimenez Diaz, Serv Dermatol, Madrid, Spain
Gonzalez, I:
Complejo Asistencial Univ Leon, Serv Dermatol, Leon, Spain
Serna, M:
Hosp Univ La Fe, Serv Dermatol, Valencia, Spain
Garces, M:
Complejo Hosp Navarra, Serv Dermatol, Pamplona, Spain
Descalzo, M:
Fdn Piel Sana, Unidad Invest, Madrid, Spain
Doval, I:
Fdn Piel Sana, Unidad Invest, Madrid, Spain
Hernando, L:
Univ Las Palmas Gran Canaria, Serv Dermot Logia, Hosp Univ Insular Gran Canaria, Las Palmas Gran Canaria, Spain
Green Published, gold
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