Exploring the universal healthy human gut microbiota around the World
Por:
Piquer-Esteban S, Ruiz-Ruiz S, Arnau V, Diaz W and Moya A
Publicada:
1 ene 2022
Ahead of Print:
1 ene 2022
Resumen:
The human gut holds a special place in the study of different microbial environments due to growing evidence that the gut microbiota is related to host health. However, despite extensive research, there is still a lack of knowledge about the core taxa forming the gut microbiota and, moreover, available information is biased towards western microbiomes in both genome databases and most core taxa studies. To tackle these limitations, we tested a database enrichment strategy and analyzed public datasets of whole-genome shotgun data, generated from 545 fecal samples, comprising three gradients of westernization. The NT database was selected as a baseline of biological diversity, subsequently being combined with various studies of interest related to the human microbiota. This enrichment strategy made it possible to improve classification capacity, compared to the original unenriched database, regarding the various lifestyles and populations studied. The effects of incomplete-taxonomy metagenome-assembled genomes on genome database enrichment were also examined, revealing that, while they are helpful, they should be used with caution depending on the taxonomic level of interest. Moreover, in terms of high prevalence, the core analysis revealed a conserved set of bacterial taxa in the healthy human gut microbiota worldwide, despite apparent lifestyle differences. Such taxa show a set of traits, metabolic roles, and ancestral status, making them suitable candidates for a hypothetical phylogenetic core of mutualistic microorganisms co-evolving with the human species. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
Filiaciones:
Piquer-Esteban S:
Institute of Integrative Systems Biology (I2Sysbio), University of València and Consejo Superior de Investigaciones Científicas (CSIC), 46980 València, Spain
Genomic and Health Area, Foundation for the Promotion of Health and Biomedical Research of València Region, 46020 València, Spain
:
Genomic and Health Area, Foundation for the Promotion of Health and Biomedical Research of València Region, 46020 València, Spain
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBEResp), 28029 Madrid, Spain
Arnau V:
Institute of Integrative Systems Biology (I2Sysbio), University of València and Consejo Superior de Investigaciones Científicas (CSIC), 46980 València, Spain
Diaz W:
Institute of Integrative Systems Biology (I2Sysbio), University of València and Consejo Superior de Investigaciones Científicas (CSIC), 46980 València, Spain
:
Institute of Integrative Systems Biology (I2Sysbio), University of València and Consejo Superior de Investigaciones Científicas (CSIC), 46980 València, Spain
Genomic and Health Area, Foundation for the Promotion of Health and Biomedical Research of València Region, 46020 València, Spain
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBEResp), 28029 Madrid, Spain
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