Microbial genome evolution: sources of variability


Por: Mira A., Klasson L. and Andersson S.G.E

Publicada: 1 oct 2002
Resumen:
Comparative genome analyses of close relatives have yielded exciting insight into the sources of microbial genome variability with respect to gene content, gene order and evolution of genes with unknown functions. The genomes of free-living bacteria often carry phages and repetitive sequences that mediate genomic rearrangements in contrast to the small genomes of obligate host-associated bacteria. This suggests that genomic stability correlates with the genomic content of repeated sequences and movable genetic elements, and thereby with bacterial lifestyle. Genes with unknown functions present in a single species tend to be shorter than conserved, functional genes, indicating that the fraction of unique genes in microbial genomes has been overestimated.

Filiaciones:
:
 Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden

Klasson L.:
 Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden

Andersson S.G.E:
 Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvägen 18C, 752 36 Uppsala, Sweden

Uppsala Univ, Evolutionary Biol Ctr, Dept Mol Evolut, S-75236 Uppsala, Sweden.
ISSN: 13695274





CURRENT OPINION IN MICROBIOLOGY
Editorial
Elsevier BV, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND, Reino Unido
Tipo de documento: Review
Volumen: 5 Número: 5
Páginas: 506-512
WOS Id: 000178901700009
ID de PubMed: 12354559

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