Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial
Por:
Laguna, J, Alegret, M, Cofan, M, Sanchez-Tainta, A, Diaz-Lopez, A, Martinez-Gonzalez, M, Sorli, J, Salas-Salvado, J, Fito, M, Alonso-Gomez, A, Serra-Majem, L, Laperra, J, Fiol, M, Gomez-Gracia, E, Pinto, X, Munoz, M, Castaner, O, Ramirez-Sabio, J, Portu, J, Estruch, R and Ros, E
Publicada:
1 oct 2021
Resumen:
Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Laguna, J:
Univ Barcelona, Dept Pharmacol Toxicol & Therapeut Chem, Sch Pharm & Food Sci, Inst Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Alegret, M:
Univ Barcelona, Dept Pharmacol Toxicol & Therapeut Chem, Sch Pharm & Food Sci, Inst Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Cofan, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Dept, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain
Sanchez-Tainta, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain
Diaz-Lopez, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Rovira & Virgili, Dept Ciencies Med Basiques, Nutr & Mental Hlth Res Grp NUTRISAM, Reus 43201, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Reus 43204, Spain
Martinez-Gonzalez, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain
Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Valencia, Dept Prevent Med, Valencia, Spain
Salas-Salvado, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Rovira & Virgili, Dept Ciencies Med Basiques, Nutr & Mental Hlth Res Grp NUTRISAM, Reus 43201, Spain
Fito, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Inst Hosp Mar Invest Med, Barcelona, Spain
Alonso-Gomez, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Basque Country UPV EHU, Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area, Osakidetza Basque Hlth Serv,Araba Univ Hosp, Vitoria, Spain
Serra-Majem, L:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Las Palmas Gran Canaria, Spain
Laperra, J:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
San Pablo Hlth Ctr JL, Dept Family Med, Primary Care Div Sevilla, Seville, Spain
Fiol, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Hosp Son Espases, Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain
Gomez-Gracia, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Malaga, Dept Prevent Med, Malaga, Spain
Pinto, X:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Dept Internal Med, Lhospitalet De Llobregat, Spain
Munoz, M:
Inst Univ Invest Atencio Primaria IDIAP Jordi Gol, Catalan Inst Hlth, Primary Care Div, Barcelona, Spain
Castaner, O:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Valencia, Dept Prevent Med, Valencia, Spain
:
Sagunto Hosp, Oncol Serv, Valencia, Spain
Portu, J:
Univ Basque Country UPV EHU, Bioaraba Hlth Res Inst, Dept Internal Med, Osakidetza Basque Hlth Serv,Araba Univ Hosp, Vitoria, Spain
Estruch, R:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Univ Barcelona, Dept Internal Med, IDIBAPS, Hosp Clin, Barcelona, Spain
Ros, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Dept, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain
Green Published, hybrid
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