Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring
Por:
Caballero-Casero, N, Belova, L, Vervliet, P, Antignac, J, Castano, A, Debrauwer, L, Lopez, M, Huber, C, Klanova, J, Krauss, M, Lommen, A, Mol, H, Oberacher, H, Pardo, O, Price, E, Reinstadler, V, Vitale, C, van Nuijs, A and Covaci, A
Publicada:
1 mar 2021
Ahead of Print:
1 feb 2021
Resumen:
Although the exposure assessment of chemicals of emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and the development of highly sophisticated analytical instruments, the lack of standardisation and harmonisation of analytical workflows and method performance assessment for suspect and non-target screening hampers the interpretation of results, their comparability and thus, its transmission to policymakers. To date, unlike in other research fields such as forensics or food analysis, there is a lack of guidelines for non-target analysis in human risk assessment and quality assurance and quality control (QA/QC) protocols. Moreover, the majority of efforts have been focused on the development and implementation of QA/QC actions for data acquisition, data analysis and mining, largely neglecting the sample preparation necessary for determination of CECs by suspect and non-target screening methods. In this article, we propose a set of QA/QC measures that covers sampling, sample preparation and data acquisition, as an aspect of work conducted within the European Biomonitoring for Europe initiative (HBM4EU). These measures include the use of standardised terminology and the implementation of dedicated QA/QC actions in each stage of the analytical process. Moreover, a framework for the analytical performance assessment has been developed for the first time for the identification of CECs in human samples by suspect and non-target approaches. Adoption of the actions proposed here for the identifi-cation of CECs in human matrices can significantly improve the comparability of reported results and contribute to the (challenging) Exposome research field. ? 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Filiaciones:
Caballero-Casero, N:
Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium
Belova, L:
Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium
Vervliet, P:
Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium
Antignac, J:
Oniris, INRAE, LABERCA, Nantes, France
Castano, A:
Inst Salud Carlos III, Natl Ctr Environm Hlth, Madrid, Spain
Debrauwer, L:
Paul Sabatier Univ, Toulouse Univ, TOXALIM Res Ctr Food Toxicol, INRAE UMR 1331,ENVT,INP Purpan, F-31027 Toulouse, France
INRAE, Metatoul AXIOM Platform, Natl Infrastruct Metabol & Flux MetaboHUB, Toxalim, F-31027 Toulouse, France
Lopez, M:
Inst Salud Carlos III, Natl Ctr Environm Hlth, Madrid, Spain
Huber, C:
UFZ, Helmholtz Ctr Environm Res, Permosers Str 15, D-04318 Leipzig, Germany
Klanova, J:
Masaryk Univ, RECETOX Ctr, Brno, Czech Republic
Krauss, M:
UFZ, Helmholtz Ctr Environm Res, Permosers Str 15, D-04318 Leipzig, Germany
Lommen, A:
Wageningen Food Safety Res, Wageningen, Netherlands
Mol, H:
Wageningen Food Safety Res, Wageningen, Netherlands
Oberacher, H:
Med Univ Innsbruck, Inst Legal Med & Core Facil Metabol, Muellerstr 44, A-6020 Innsbruck, Austria
:
FISABIO Publ Hlth, Fdn Promot Hlth & Biomed Res Valencia Reg, Ave Catalunya 21, Valencia 46020, Spain
Price, E:
Masaryk Univ, RECETOX Ctr, Brno, Czech Republic
Masaryk Univ, Fac Sports Studies, Brno, Czech Republic
Reinstadler, V:
Med Univ Innsbruck, Inst Legal Med & Core Facil Metabol, Muellerstr 44, A-6020 Innsbruck, Austria
Vitale, C:
Masaryk Univ, RECETOX Ctr, Brno, Czech Republic
van Nuijs, A:
Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium
Covaci, A:
Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium
Green Published, hybrid
|