Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network
Por:
Puig-Barberà J, Natividad-Sancho A, Trushakova S, Sominina A, Pisareva M, Ciblak MA, Badur S, Yu H, Cowling BJ, El Guerche-Séblain C, Mira-Iglesias A, Kisteneva L, Stolyarov K, Yurtcu K, Feng L, López-Labrador X, Burtseva E and Global Influenza Hospital Surveillance Study Group (GIHSN)
Publicada:
19 may 2016
Resumen:
Background
The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations.
Methods
Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression.
Findings
5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]).
Conclusions
Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission.
Filiaciones:
:
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Valencia, Spain
:
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Valencia, Spain
Trushakova S:
D.I. Ivanovsky Institute of Virology FSBI "N.F. Gamaleya FRCEM" Ministry of Health of Russian Federation, Moscow, Russian Federation
Sominina A:
Research Institute of Influenza, St. Petersburg, Russian Federation
Pisareva M:
Research Institute of Influenza, St. Petersburg, Russian Federation
Ciblak MA:
National Influenza Reference Laboratory, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Badur S:
National Influenza Reference Laboratory, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Yu H:
Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China
Cowling BJ:
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
El Guerche-Séblain C:
Sanofi Pasteur, Lyon, France
:
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Valencia, Spain
Kisteneva L:
D.I. Ivanovsky Institute of Virology FSBI "N.F. Gamaleya FRCEM" Ministry of Health of Russian Federation, Moscow, Russian Federation
Stolyarov K:
Research Institute of Influenza, St. Petersburg, Russian Federation
Yurtcu K:
National Influenza Reference Laboratory, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Feng L:
Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China
López-Labrador X:
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Valencia, Spain
Centro de Investigación Biomédica en Epidemiología y Salud Publica (CIBER-ESP), Instituto de Salud Carlos III, Madrid, Spain
Burtseva E:
D.I. Ivanovsky Institute of Virology FSBI "N.F. Gamaleya FRCEM" Ministry of Health of Russian Federation, Moscow, Russian Federation
Green Published, Green Submitted, gold
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