Economic burden of multiple sclerosis in a population with low physical disability
Por:
Garcia-Dominguez, J, Maurino, J, Martinez-Gines, M, Carmona, O, Medrano, N, Ruiz-Beato, E, Ares, A, Arnal, C, Caminero, A, Carcelen, M, Eguia, P, Fernandez, M, Ginestal, R, Lacruz, L, Llaneza, M, de Silanes, C, Martin, G, Navarro, L, Romero, B, Seral, M, Solar, M and W-IMPACT Clinical Investigators
Publicada:
20 may 2019
Categoría:
Public health, environmental and occupational health
Resumen:
BackgroundIn multiple sclerosis (MS), half of affected people are unemployed within 10years of diagnosis. The aim of this study was to assess the economic impact of MS in adult subjects with relapsing-remitting MS (RRMS) and primary progressive MS (PPMS).MethodsA multicenter, non-interventional, cross-sectional study was conducted. The Expanded Disability Status Scale (EDSS) and the 23-item Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) were used to assess disability and work performance, respectively. Only indirect costs were considered using the human capital method, including work costs. Professional support costs and informal caregivers' costs were also estimated.ResultsA total of 199 subjects were studied (mean age: 43.910.5years, 60.8% female, 86.4% with RRMS). Median EDSS score was 2.0 (interquartile range: 1.0-3.5) and median MSWDQ-23 total score was 31.5 (15.2, 50.0). The number of employed subjects decreased after MS diagnosis from 70.6 to 47.2%, and the number of retired people increased (23.6%). Mean age of retirement was 43.6 +/- 10.5years. Ten percent of the population had sick leaves (absenteeism was seen in 90.9% of the student population and 30.9% of the employed population). Professional support in their daily life activities was needed in 28.1% of subjects. Costs for sick leave, work absenteeism, premature retirement and premature work disability/pensioner were Euro416.6 +/- 2030.2, Euro763.4 +/- 3161.8, Euro5810.1 +/- 13,159.0 and Euro1816.8 +/- 9630.7, respectively. Costs for professional support and informal caregiving activities were Euro1026.93 +/- 4622.0 and Euro1328.72, respectively.Conclusions p id=Par4 MS is responsible for a substantial economic burden due to indirect and informal care costs, even in a population with low physical disability.
Filiaciones:
Garcia-Dominguez, J:
Hosp Univ Gregorio Maranon, Dept Neurol, Madrid, Spain
Hosp Univ Gregorio Maranon, Madrid, Spain
Maurino, J:
Roche Farma, Med Dept, Ribera Loira 50, Madrid 28042, Spain
Martinez-Gines, M:
Hosp Univ Gregorio Maranon, Dept Neurol, Madrid, Spain
Hosp Univ Gregorio Maranon, Madrid, Spain
Carmona, O:
Hosp Figueres, Dept Neurol, Figueres, Spain
Hosp Figueres, Figueres, Spain
Medrano, N:
Roche Farma, Med Dept, Ribera Loira 50, Madrid 28042, Spain
Ruiz-Beato, E:
Roche Farma, Hlth Econ & Outcomes Res Unit, Madrid, Spain
Ares, A:
Complejo Asistencial Univ Leon, Leon, Spain
Arnal, C:
Complejo Hosp Univ Granada, Granada, Spain
Caminero, A:
Hosp Nuestra Senora Sonsoles, Dept Neurol, Complejo Asistencial Avila, Avila, Spain
Hosp Nuestra Senora Sonsoles, Avila, Spain
Carcelen, M:
Hosp Gen Univ Valencia, Valencia, Spain
Eguia, P:
Hosp Dr Jose Molina Orosa, Lanzarote, Spain
Fernandez, M:
Hosp Univ Virgen Valme, Seville, Spain
Ginestal, R:
Hosp Univ Clin San Carlos, Madrid, Spain
:
Hosp Francesc Borja, Gandia, Spain
Llaneza, M:
Hosp Arquitecto Marcide, Ferrol, Spain
de Silanes, C:
Hosp Torrejon, Torrejon De Ardoz, Spain
Martin, G:
Hosp Verge Cinta, Tortosa, Spain
:
Hosp Gen Univ Elche, Elche, Spain
Romero, B:
Hosp Son Llatzer, Palma De Mallorca, Spain
Seral, M:
Hosp Gen San Jorge, Huesca, Spain
Solar, M:
Hosp Univ Cabuenes, Gijon, Spain
Green Published, gold
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