HIV infection results in metabolic alterations in the gut microbiota different from those induced by other diseases


Por: Serrano-Villar S, Rojo D, Martínez-Martínez M, Deusch S, Vázquez-Castellanos JF, Sainz T, Vera M, Moreno S, Estrada V, Gosalbes MJ, Latorre A, Margolles A, Seifert J, Barbas C, Moya A and Ferrer M

Publicada: 18 may 2016 Ahead of Print: 18 may 2016
Categoría: Multidisciplinary

Resumen:
Imbalances in gut bacteria have been associated with multiple diseases. However, whether there are disease-specific changes in gut microbial metabolism remains unknown. Here, we demonstrate that human immunodeficiency virus (HIV) infection (n = 33) changes, at quantifiable levels, the metabolism of gut bacteria. These changes are different than those observed in patients with the auto-immune disease systemic lupus erythaematosus (n = 18), and Clostridium difficile-associated diarrhoea (n = 6). Using healthy controls as a baseline (n = 16), we demonstrate that a trend in the nature and directionality of the metabolic changes exists according to the type of the disease. The impact on the gut microbial activity, and thus the metabolite composition and metabolic flux of gut microbes, is therefore disease-dependent. Our data further provide experimental evidence that HIV infection drastically changed the microbial community, and the species responsible for the metabolism of 4 amino acids, in contrast to patients with the other two diseases and healthy controls. The identification in this present work of specific metabolic deficits in HIV-infected patients may define nutritional supplements to improve the health of these patients.

Filiaciones:
Serrano-Villar S:
 Department of Infectious Diseases, University Hospital Ramón y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain

Rojo D:
 Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Madrid, Spain

Martínez-Martínez M:
 Institute of Catalysis, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

Deusch S:
 Institute of Animal Science, Universität Hohenheim, Stuttgart, Germany

:
 Foundation for the Promotion of Health and Biomedical Research in the Valencian Community (FISABIO) - Public Health, Valencia, Spain

 Network Research Center for Epidemiology and Public Health (CIBER-ESP), Madrid, Spain

Sainz T:
 Department of Pediatric Infectious Diseases, University Hospital La Paz, and La Paz Research Institute (IdiPAZ), Madrid, Spain

Vera M:
 Centro Sanitario Sandoval, Madrid, Spain

Moreno S:
 Department of Infectious Diseases, University Hospital Ramón y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain

Estrada V:
 HIV Unit, Department of Internal Medicine, University Hospital Clínico San Carlos, Madrid, Spain

:
 Foundation for the Promotion of Health and Biomedical Research in the Valencian Community (FISABIO) - Public Health, Valencia, Spain

 Network Research Center for Epidemiology and Public Health (CIBER-ESP), Madrid, Spain

:
 Foundation for the Promotion of Health and Biomedical Research in the Valencian Community (FISABIO) - Public Health, Valencia, Spain

 Network Research Center for Epidemiology and Public Health (CIBER-ESP), Madrid, Spain

 Instituto Cavanilles de Biodiversidad y Biología Evolutiva (Universidad de Valencia), Valencia, Spain

Margolles A:
 Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute (IPLA), CSIC, Villaviciosa, Asturias, Spain

Seifert J:
 Institute of Animal Science, Universität Hohenheim, Stuttgart, Germany

Barbas C:
 Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad CEU San Pablo, Campus Montepríncipe, Madrid, Spain

:
 Foundation for the Promotion of Health and Biomedical Research in the Valencian Community (FISABIO) - Public Health, Valencia, Spain

 Network Research Center for Epidemiology and Public Health (CIBER-ESP), Madrid, Spain

 Instituto Cavanilles de Biodiversidad y Biología Evolutiva (Universidad de Valencia), Valencia, Spain

Ferrer M:
 Institute of Catalysis, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
ISSN: 20452322





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Editorial
NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 6 Número:
Páginas: 26192-26192
WOS Id: 000375994000005
ID de PubMed: 27189771
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