Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study
Por:
Companys, J, Gosalbes, M, Pla-Paga, L, Calderon-Perez, L, Llaurado, E, Pedret, A, Valls, R, Jimenez-Hernandez, N, Sandoval-Ramirez, B, del Bas, J, Caimari, A, Rubio, L and Sola, R
Publicada:
1 jun 2021
Resumen:
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.
Filiaciones:
Companys, J:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
:
Fdn el Fomento Invest Sanitaria & Biomed, Valencia 46020, Spain
CIBER Epidemiol & Salud Publ, Madrid 28029, Spain
Pla-Paga, L:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
Calderon-Perez, L:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
Llaurado, E:
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
Pedret, A:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
Valls, R:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
:
Fdn el Fomento Invest Sanitaria & Biomed, Valencia 46020, Spain
CIBER Epidemiol & Salud Publ, Madrid 28029, Spain
Sandoval-Ramirez, B:
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
del Bas, J:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Caimari, A:
Ctr Tecnol Catalunya, Eurecat, Biotechnol Area, Reus 43204, Spain
Rubio, L:
Univ Lleida, Escola Tecn Super Engn Agr, Agrotecnio Ctr, XaRTA TPV,Food Technol Dept, Avda Alcalde Rovira Roure 191, Catalonia 25198, Spain
Sola, R:
Ctr Tecnol Catalunya, Eurecat, Unitat Nutr & Salut, Reus 43204, Spain
Univ Rovira & Virgili, Fac Med & Ciencies Salut, Funct Nutr Oxidat & Cardiovasc Dis Grp NFOCS Salu, C Sant Llorenc 21, Reus 43201, Spain
Hosp Univ St Joan Reus, Reus 43201, Spain
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