Relationship between the Risk of Gastric Cancer and Adherence to the Mediterranean Diet According to Different Estimators. MCC-Spain Study


Por: Álvarez-Álvarez L, Vitelli-Storelli F, Rubín-García M, Aragonés N, Ardanaz E, Castaño-Vinyals G, Obón-Santacana M, Dierssen-Sotos T, Salas-Trejo D, Tardón A, Moleón JJJ, Alguacil J, Chirlaque MD, Pérez-Gómez B, Pollán M, Kogevinas M and Martín V

Publicada: 1 nov 2021 Ahead of Print: 21 oct 2021
Resumen:
Dietary habits are one of the factors that influence the development of gastric cancer and, although it has been seen that the Mediterranean diet has a protective effect on this type of cancer, there are different indexes to assess the degree of adherence to this dietary pattern; this implies differences in the results obtained in the reduction of risk. The aim of this work was to assess the effect of adherence to the Mediterranean diet, measured with five different indexes, on the risk of gastric cancer. The aim was to assess the effect of adherence to the Mediterranean Diet, measured with five different indexes, on the risk of gastric cancer. Data come from the multicase-control study MCC-Spain, which included 354 gastric cancer cases and 3040 controls with data on diet. We used five indexes to evaluate adherence to the Mediterranean diet and assess the association between each pattern with the risk of gastric cancer, using multivariate logistic regression. The analyses were performed for the whole set of gastric cancer cases, by anatomical location (cardia and non-cardia) and by histological type (intestinal and diffuse). According to the used index, a high adherence protects one from gastric cancer (between 48% (aOR = 0.52; CI 95% = 0.28-0.94) and 75% (aOR = 0.25; CI 95% = 0.12-0.52)), from non-cardia (between 48% (aOR = 0.52; CI 95% = 0.36-0.75) and 65% (aOR = 0.35; CI 95% = 0.23-0.52)), and from the intestinal type (between 41% (aOR = 0.59; CI 95% = 0.36-0.95) and 72% (aOR = 0.28; CI 95% = 0.16-0.50)), but not from the diffuse type. In conclusion, high adherence to a Mediterranean diet pattern is a protective factor for the risk of gastric cancer, with greater adherence leading to greater protection.

Filiaciones:
Álvarez-Álvarez L:
 Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain

Vitelli-Storelli F:
 Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain

Rubín-García M:
 Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain

Aragonés N:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, 28035 Madrid, Spain

Ardanaz E:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Navarra Institute for Health Research (IdiSNA) Navarra Public Health Institute, 31008 Pamplona, Spain

Castaño-Vinyals G:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), 08036 Barcelona, Spain

Obón-Santacana M:
 Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet Del Llobregat, 08908 Barcelona, Spain

Dierssen-Sotos T:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Universidad de Cantabria-IDIVAL, 39005 Santander, Spain

:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Valencian Breast Cancer Screening Program, General Directorate of Public Health, 46020 València, Spain

Tardón A:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Department of Medicine, University of Oviedo, 33003 Oviedo, Spain

Moleón JJJ:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada, Universidad de Granada, 18012 Granada, Spain

Alguacil J:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Campus Universitario de El Carmen, 21004 Huelva, Spain

Chirlaque MD:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30008 Murcia, Spain

Pérez-Gómez B:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain

Pollán M:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Cancer and Environmental Epidemiology Unit, Department of Epidemiology and Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain

Kogevinas M:
 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain

 Institute of Global Health (ISGlobal), 08036 Barcelona, Spain

Martín V:
 Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain

 Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain
ISSN: 20726694





Cancers
Editorial
Multidisciplinary Digital Publishing Institute (MDPI), ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, Suiza
Tipo de documento: Article
Volumen: 13 Número: 21
Páginas:
WOS Id: 000719121200001
ID de PubMed: 34771444
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