European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender.
Por:
Seppälä TT, Latchford A, Negoi I, Sampaio Soares A, Jimenez-Rodriguez R, Sánchez-Guillén L, Evans DG, Ryan N, Crosbie EJ, Dominguez-Valentin M, Burn J, Kloor M, Knebel Doeberitz MV, Duijnhoven FJBV, Quirke P, Sampson JR, Møller P, Möslein G and European Hereditary Tumour Group (EHTG) and European Society of Coloproctology
Publicada:
27 may 2021
Ahead of Print:
1 sep 2020
Categoría:
Surgery
Resumen:
BACKGROUND: Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of the effectiveness of colonoscopic surveillance and the heterogeneity of cancer risk between genotypes. The need for gene- and gender-specific guidelines has been acknowledged. METHODS: The European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP) developed a multidisciplinary working group consisting of surgeons, clinical and molecular geneticists, pathologists, epidemiologists, gastroenterologists, and patient representation to conduct a graded evidence review. The previous Mallorca guideline format was used to revise the clinical guidance. Consensus for the guidance statements was acquired by three Delphi voting rounds. RESULTS: Recommendations for clinical and molecular identification of Lynch syndrome, surgical and endoscopic management of Lynch syndrome-associated colorectal cancer, and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum. Manchester consensus guidelines for gynaecological management were endorsed. Executive and layperson summaries were provided. CONCLUSION: The recommendations from the EHTG and ESCP for identification of patients with Lynch syndrome, colorectal surveillance, surgical management of colorectal cancer, lifestyle and chemoprevention in Lynch syndrome that reached a consensus (at least 80 per cent) are presented.
Filiaciones:
Seppälä TT:
Department of Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Department of Surgical Oncology, Johns Hopkins Hospital, Baltimore Maryland, USA
Latchford A:
Department of Cancer and Surgery, Imperial College London, UK
St Mark's Hospital, London North West Healthcare NHS Trust, London, UK
Negoi I:
Department of Surgery, Emergency Hospital of Bucharest, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Sampaio Soares A:
Hospital Prof. Dr Fernando Fonseca, EPE, Lisbon, Portugal
Jimenez-Rodriguez R:
Department of Surgery, Hospital Universitario Virgen del Rocío, Seville, Spain
:
Colorectal Unit, Department of General Surgery, Elche University General Hospital Elche, Alicante, Spain
Evans DG:
Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, University of Manchester, Manchester University Hospitals NHS Foundation Trust, UK
Ryan N:
Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK
Centre for Academic Women's Health, University of Bristol, Bristol, UK
Crosbie EJ:
Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK
Dominguez-Valentin M:
Department of Tumour Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Burn J:
Faculty of Medical Sciences, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
Kloor M:
Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Germany
Cooperation Unit Applied Tumour Biology, German Cancer Research Centre, Heidelberg, Germany
Knebel Doeberitz MV:
Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Germany
Cooperation Unit Applied Tumour Biology, German Cancer Research Centre, Heidelberg, Germany
Duijnhoven FJBV:
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands
Quirke P:
Pathology and Data Analytics, School of Medicine, University of Leeds, Leeds, UK
Sampson JR:
Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, UK
Møller P:
Department of Tumour Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
University of Witten/Herdecke, Witten, Germany
Möslein G:
Centre for Hereditary Tumours, Bethesda Hospital, Duisburg, Germany
University of Witten/Herdecke, Witten, Germany
Green Published, Green Accepted
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