Falls Predict Acute Hospitalization in Parkinson's Disease
Por:
Santos García D, de Deus Fonticoba T, Cores C, Castro ES, Hernández Vara J, Jesús S, Mir P, Cosgaya M, Martí MJ, Pastor P, Cabo I, Seijo M, Legarda I, Vives B, Caballol N, Rúiz Martínez J, Croitoru I, Cubo E, Miranda J, Alonso Losada MG, Labandeira C, López Ariztegui N, Morales-Casado M, González Aramburu I, Infante J, Escalante S, Bernardo N, Blázquez Estrada M, Menéndez González M, Caldentey JG, Borrué C, Vela L, Catalán MJ, Gómez Mayordomo V, Kurtis M, Prieto C, Ordás C, Nogueira V, López Manzanares L, Ávila Rivera MA, Puente V, García Moreno JM, Solano Vila B, Álvarez Sauco M, Carrillo Padilla F, Carlos Martínez Castrillo J, Sánchez Alonso P, Gastón I, Kulisevsky J, Valero C, de Fábregues O, González Ardura J, López Díaz LM and Martinez-Martin P
Publicada:
1 ene 2023
Ahead of Print:
7 abr 2021
Resumen:
Background: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission.
Objective: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort.
Methods: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit.
Results: Thirty-five out of 605 (5.8%) PD patients (62.5 +/- 8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH.
Conclusion: Falls is an independent predictor of AH in PD patients.
Filiaciones:
Santos García D:
CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain
de Deus Fonticoba T:
CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain
Cores C:
CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain
Castro ES:
CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain
Hernández Vara J:
Neurology Department and Neurodegenerative Diseases Research. Vall D'Hebron Universitary Campus, Barcelona, Spain
Jesús S:
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Spain
Mir P:
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Spain
Cosgaya M:
Hospital Clinic de Barcelona, Barcelona, Spain
Martí MJ:
Hospital Clinic de Barcelona, Barcelona, Spain
Pastor P:
Movement disorders Unit, University Hospital Mutua de Terrassa, Barcelona, Spain
Cabo I:
Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain
Seijo M:
Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain
Legarda I:
Hospital Universitario Son Espases, Palma de Mallorca, Spain
Vives B:
Hospital Universitario Son Espases, Palma de Mallorca, Spain
Caballol N:
Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain
Rúiz Martínez J:
Hospital Universitario Donostia, San Sebastián, Spain
Croitoru I:
Hospital Universitario Donostia, San Sebastián, Spain
Cubo E:
Complejo Asistencial Universitario de Burgos, Burgos, Spain
Miranda J:
Complejo Asistencial Universitario de Burgos, Burgos, Spain
Alonso Losada MG:
Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain
Labandeira C:
Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain
López Ariztegui N:
Complejo Hospitalario de Toledo, Toledo, Spain
Morales-Casado M:
Complejo Hospitalario de Toledo, Toledo, Spain
González Aramburu I:
Hospital Universitario Marqués de Valdecilla, Santander, Spain
Infante J:
Hospital Universitario Marqués de Valdecilla, Santander, Spain
Escalante S:
Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain
Bernardo N:
Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain
Blázquez Estrada M:
Hospital Universitario Central de Asturias, Oviedo, Spain
Menéndez González M:
Movement disorders Unit, University Hospital Mutua de Terrassa, Barcelona, Spain
Caldentey JG:
Centro Neurológico Oms, Palma de Mallorca, Spain
Borrué C:
Hospital Infanta Sofía, Madrid, Spain
Vela L:
Fundación Hospital de Alcorcón, Madrid, Spain
Catalán MJ:
Hospital Universitario Clínico San Carlos, Madrid, Spain
Gómez Mayordomo V:
Hospital Universitario Clínico San Carlos, Madrid, Spain
Kurtis M:
Hospital Ruber Internacional, Madrid, Spain
Prieto C:
Hospital Rey Juan Carlos, Madrid, Spain
Ordás C:
Hospital Rey Juan Carlos, Madrid, Spain
Nogueira V:
Hospital Da Costa, Burela, Lugo, Spain
López Manzanares L:
Hospital Universitario La Princesa, Madrid, Spain
Ávila Rivera MA:
Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Barcelona, Spain
Puente V:
Hospital del Mar, Barcelona, Spain
García Moreno JM:
Hospital Universitario Virgen Macarena, Sevilla, Spain
Solano Vila B:
Institut d'Assistència Sanitària (IAS) - Institut Català de la Salut. Girona, Spain
:
Hospital General Universitario de Elche, Elche, Spain
Carrillo Padilla F:
Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain
Carlos Martínez Castrillo J:
Hospital Universitario Ramón Y Cajal, Madrid, Spain
Sánchez Alonso P:
Hospital Universitario Puerta de Hierro, Madrid, Spain
Gastón I:
Complejo Hospitalario de Navarra, Pamplona, Spain
Kulisevsky J:
CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Spain
Hospital de Sant Pau, Barcelona, Spain
:
Hospital Arnau de Vilanova, Valencia, Spain
de Fábregues O:
Neurology Department and Neurodegenerative Diseases Research. Vall D'Hebron Universitary Campus, Barcelona, Spain
González Ardura J:
Hospital Universitario Lucus Augusti (HULA), Lugo, Spain
López Díaz LM:
Complejo Hospitalario Universitario de Orense (CHUO), Orense, Spain
Martinez-Martin P:
CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Spain
gold, Green Published
|