Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial
Por:
Climent, E, Martinez-Blanch, J, Llobregat, L, Ruzafa-Costas, B, Carrion-Gutierrez, M, Ramirez-Bosca, A, Prieto-Merino, D, Genoves, S, Codoner, F, Ramon, D, Chenoll, E and Navarro-Lopez, V
Publicada:
1 abr 2021
Ahead of Print:
15 abr 2021
Resumen:
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy and a high prevalence of relapses. Because of the limited effectiveness of these treatments, new strategies for recovery from AD lesions are continually being explored. In this article, we describe the gut microbiome changes achieved in a recently published clinical trial with the probiotic formulation Bifidobacterium animalis subsp. lactis CECT 8145, Bifidobacterium longum CECT 7347, and Lacticaseibacillus casei CECT 9104 (formerly Lactobacillus casei CECT 9104), showing a significant improvement in SCORAD (scoring atopic dermatitis) index in children (4-17 years) with AD (Clinicaltrials.gov identifier: NCT02585986). The present gut microbiome post hoc study showed no significant changes in diversity (Shannon and Simpson indexes) after probiotic consumption. In the probiotic group, genera Bacteroides, Ruminococcus, and Bifidobacterium significantly increased their levels while Faecalibacterium decreased, compared to the placebo group. Faecalibacterium showed the highest presence and significant positive correlation with AD severity (SCORAD index), whereas Abyssivirga, Bifidobacterium, and Lactococcus were inversely correlated. The results suggest that the consumption of the probiotic formulation here assayed modulates the gut microbiome with significant changes in genera Bacteroides and Faecalibacterium. In turn, the improvement in SCORAD correlates with a decrease in Faecalibacterium and an increase in Bifidobacterium, among others.
Filiaciones:
Climent, E:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
Martinez-Blanch, J:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
Llobregat, L:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
Ruzafa-Costas, B:
Univ Catolica San Antonio Murcia UCAM, Dept Clin Med, Murcia 30107, Spain
Carrion-Gutierrez, M:
Especialida Farmaceut Ctr, Calle Sagitario 14, Alicante 03006, Spain
:
Univ Catolica San Antonio Murcia UCAM, Dept Clin Med, Murcia 30107, Spain
Hosp Univ Vinalopo, Dept Dermatol, Elche 03293, Spain
Prieto-Merino, D:
Univ Catolica San Antonio Murcia UCAM, Appl Stat Methods Med Res Grp, Murcia 30107, Spain
London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London 400706, England
Genoves, S:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
Codoner, F:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
Ramon, D:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
Chenoll, E:
Biopolis SL ADM, Catedratico Agustin Escardino Benlloch 9 Edif 2, Paterna 46980, Spain
:
Univ Catolica San Antonio Murcia UCAM, Dept Clin Med, Murcia 30107, Spain
Hosp Univ Vinalopo, Clin Microbiol & Infect Dis Unit, Elche 03293, Spain
gold, Green Published
|