Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty (R) COVID-19 vaccine in nursing home residents
Por:
Albert E, Burgos JS, Peiró S, Salas D, Vanaclocha H, Giménez E, Limón R, Alcaraz MJ, Sánchez-Payá J, Díez-Domingo J and Navarro D
Publicada:
1 feb 2022
Ahead of Print:
1 ene 2022
Resumen:
Objectives: The current study was aimed at examining SARS-CoV-2 immune responses following two doses of Comirnaty (R) COVID-19 vaccine among elderly people in nursing homes.
Methods: A prospective cohort study in a representative sample from nursing homes in Valencia (n = 881; males: 271, females 610; median age, 86 years) recruited residents using a random one-stage cluster sampling approach. A lateral flow immunochromatography device (LFIC) (OnSite COVID-19 IgG/IgM Rapid Test; CTK BIOTECH, Poway, CA, USA) was used as the front-line test for detecting SARS-CoV-2-Spike (S)-specific antibodies in whole blood obtained using a fingerstick. Residents returning negative LFIC results underwent venipuncture and testing for presence of SARS-CoV-2-S-reactive antibodies and T cells using the Roche Elecsys (R) Anti-SARS-CoV-2 S (Roche Diagnostics, Pleasanton, CA, USA), the LIAISON (R) SARS-CoV-2 TrimericS IgG assay (Diasorin S.p.A, Saluggia, Italy) and by flow cytometry, respectively.
Results: The SARS-CoV-2-S antibody detection rate in nursing home residents was 99.6% (283/284) and 98.3% (587/597) for SARS-CoV-2 recovered and naive residents, respectively, within a median of 99 days (range 17-125 days) after full vaccination. Three out of five residents lacking SARS-CoV-2-S antibodies had detectable S-reactive CD8(+) and/or CD4(+) T cells. In addition, 50/50 and 40/50 participants with detectable SARS-CoV-2 antibodies also had SARS-CoV-2-S reactive interferon-gamma-producing CD4(+) and CD8(+) T cells, respectively.
Discussion: The Comirnaty (R) COVID-19 vaccine is highly immunogenic in nursing home residents. (C) 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Filiaciones:
Albert E:
Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain
Burgos JS:
General Directorate of Research and Healthcare Supervision, Department of Health, Valencia Government, Valencia, Spain
:
Foundation for the promotion of health and biomedical research of the Valencian Community (FISABIO), Valencia, Spain
:
Foundation for the promotion of health and biomedical research of the Valencian Community (FISABIO), Valencia, Spain
General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain
:
General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain
Giménez E:
Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain
Limón R:
General Directorate of Healthcare, Department of Health, Valencian Government, València, Spain
Alcaraz MJ:
Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain
Sánchez-Payá J:
Preventive Medicine Service, Alicante General and University Hospital, Alicante, Spain
Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain
:
Foundation for the promotion of health and biomedical research of the Valencian Community (FISABIO), Valencia, Spain
Navarro D:
Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain
Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain
Burgos JS:
General Directorate of Research and Healthcare Supervision, Department of Health, Valencia Government, Valencia, Spain
Meneu de Guillerna R:
Vice-President Foundation Research Institute in Public Services, Valencia, Spain
Vanaclocha Luna H:
General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain
Burks DJ:
The Prince Felipe Research Center-CIPF-, Valencia, Spain
Cervantes A:
INCLIVA Health Research Institute, Valencia, Spain
:
Biomedicine Institute of Valencia, Spanish Research Council (CSIC)
:
Foundation for the promotion of health and biomedical research of the Valencian Community-FISABIO-, Valencia, Spain
:
Foundation for the promotion of health and biomedical research of the Valencian Community-FISABIO-, Valencia, Spain
:
CIBER in Epidemiology and Public Health, Spain
Joint Research Unit "Infection and Public Health" FISABIO-University of Valencia, Valencia, Spain
Institute for Integrative Systems Biology (I2SysBio), CSIC-University of Valencia, Valencia, Spain
Ferrer Albiach C:
Fundación Hospital Provincial de Castelló
Hernández-Aguado I:
University Miguel Hernández, Alicante, Spain
Oliver Ramírez N:
DataPop Alliance
Sánchez-Payá J:
Preventive Medicine Service, Alicante General and University Hospital, Alicante, Spain
Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain
Vento Torres M:
Instituto de Investigación Sanitaria La Fe
Zapater Latorre E:
Fundación Hospital General Universitario de València
Navarro D:
Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain
Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain
Green Published
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