Dosage of anti-PD-1 monoclonal antibodies: a cardinal open question
Por:
Sureda, M, Calvo, E, Mata, J, Escudero-Ortiz, V, Martinez-Navarro, E, Catalan, A and Rebollo, J
Publicada:
1 ago 2021
Ahead of Print:
1 feb 2021
Resumen:
Discovery and clinical development of monoclonal antibodies with the ability to interfere in the regulation of the immune response have significantly changed the landscape of oncology in recent years. Among the active agents licensed by the regulatory agencies, nivolumab and pembrolizumab are paradigmatic as the most relevant ones according to the magnitude of available data derived from the extensive preclinical and clinical experience. Although in both cases the respective data sheets indicate well-defined dosage regimens, a review of the literature permits to verify the existence of many issues still unresolved about dosing the two agents, so it must be considered an open question of potentially important consequences, in which to work to improve the effectiveness and efficiency of use.
Filiaciones:
Sureda, M:
Hosp Quironsalud Torrevieja, Plataforma Oncol, C Partida Loma S-N, Alicante 03184, Spain
Calvo, E:
Hosp Univ HM Sanchinarro, START Madrid Ctr Integral Oncol Clara Campal, Madrid, Spain
Mata, J:
Hosp Quironsalud Torrevieja, Plataforma Oncol, C Partida Loma S-N, Alicante 03184, Spain
:
Hosp Quironsalud Torrevieja, Plataforma Oncol, C Partida Loma S-N, Alicante 03184, Spain
Martinez-Navarro, E:
Hosp Quironsalud Torrevieja, Plataforma Oncol, C Partida Loma S-N, Alicante 03184, Spain
Catalan, A:
Hosp Quironsalud Torrevieja, Plataforma Oncol, C Partida Loma S-N, Alicante 03184, Spain
Rebollo, J:
Hosp Quironsalud Torrevieja, Plataforma Oncol, C Partida Loma S-N, Alicante 03184, Spain
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