Sodium-Glucose Cotransporter-2 Inhibitors at Discharge from Cardiology Hospitalization Department: Decoding A New Clinical Scenario
Por:
Rozado, J, Iglesias, D, Soroa, M, Junco-Vicente, A, Barja, N, Adeba, A, Vigil-Escalera, M, Alvarez, R, Saura, F, Capin, E, Garcia, L, Rodriguez, M, Calvo, D, Moris, C, Delgado, E and de la Hera, J
Publicada:
1 ago 2020
Categoría:
Medicine (miscellaneous)
Resumen:
Sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are new glucose-lowering drugs (GLDs) with demonstrated cardiovascular benefits in patients with heart disease and type-2 diabetes mellitus (T2DM). However, their safety and efficacy when prescribed at hospital discharge are unexplored. This prospective, observational, longitudinal cohort study included 104 consecutive T2DM patients discharged from the cardiology department between April 2018 and February 2019. Patients were classified based on SGLT-2 inhibitor prescription and adjusted by propensity-score matching. The safety outcomes included discontinuation of GLDs; worsening renal function; and renal, hepatic, or metabolic hospitalization. The efficacy outcomes were death from any cause, cardiovascular death, cardiovascular readmission, and combined clinical outcome (cardiovascular death or readmission). The results showed that, the incidence rates of safety outcomes were similar in the SGLT-2 inhibitor or non-SGLT-2 inhibitor groups. Regarding efficacy, the SGLT-2 inhibitors group resulted in a lower rate of combined clinical outcomes (18% vs. 42%; hazard ratio (HR), 0.35;p= 0.02), any cause death (0% vs. 24%; HR, 0.79;p= 0.001) and cardiovascular death (0% vs. 17%; HR, 0.83;p= 0.005). No significant differences were found in cardiovascular readmissions. SGLT-2 inhibitor prescription at hospital discharge in patients with heart disease and T2DM was safe, well tolerated, and associated with a reduction in all-cause and cardiovascular deaths.
Filiaciones:
Rozado, J:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Iglesias, D:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Soroa, M:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Junco-Vicente, A:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Barja, N:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Adeba, A:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Vigil-Escalera, M:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Alvarez, R:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
:
Hosp Univ Vinalopo, Dept Cardiol, Torrevieja 03293, Spain
Hosp Univ Torrevieja, Torrevieja 03293, Spain
Capin, E:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Garcia, L:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Rodriguez, M:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Calvo, D:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Moris, C:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Univ Oviedo, Med Dept, Oviedo 33011, Spain
Delgado, E:
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Univ Oviedo, Med Dept, Oviedo 33011, Spain
Hosp Univ Cent Asturias, Dept Endocrinol, Oviedo 33011, Spain
de la Hera, J:
Hosp Univ Cent Asturias, Dept Cardiol, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
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