Study of the Vaginal Microbiota in Healthy Women of Reproductive Age
Por:
Martinez, M, Cazorla, E, Canovas, E, Martinez-Blanch, J, Chenoll, E, Climent, E and Navarro-Lopez, V
Publicada:
1 may 2021
Resumen:
Understanding the characteristics of the vaginal microbiota of our patients allows us to carry out both a personalized therapeutic approach and a closer follow-up in those with microbiota susceptible to dysbiosis. This trial pursues the analysis of the vaginal microbiota of premenopausal women and its fluctuations within a four-week follow-up period. Vaginal samples of 76 fertile women were taken at a baseline visit and at a final visit (day 28 +/- 5). To perform a phylogenetic study, we employed massive sequencing techniques to detect the 16S rRNA gene of the vaginal microbiota. The most prevalent vaginal microbial community was type I (34.87%), dominated by Lactobacillus crispatus. Vaginal microbial community types II (Lactobacillus gasseri) and V (Lactobacillus jensenii) were underrepresented in our population. When repeating the sampling process four weeks later, 75% of our patients maintained their initial bacterial community. In the follicular phase, the most recurrent microbiota was type III (Lactobacillus iners); in the periovulatory phase, types III and IV (microbial diversity); finally, in the luteal phase, the most frequent type was IV. The most prevalent vaginal bacterial community in our population was dominated by L. crispatus. The vaginal microbiota was resistant to changes in its bacterial community in 75% of our patients, even between consecutive menstrual cycles.
Filiaciones:
:
Catholic Univ Murcia UCAM, PhD Program Hlth Sci, Campus Jeronimos 135, Murcia 30107, Spain
Univ Hosp Torrevieja, Carretera CV 95 S-N, Alicante 03186, Spain
Catholic Univ Murcia, MiBioPath Grp, Campus Jeronimos 135, Murcia 30107, Spain
:
Univ Hosp Torrevieja, Carretera CV 95 S-N, Alicante 03186, Spain
Catholic Univ Murcia, MiBioPath Grp, Campus Jeronimos 135, Murcia 30107, Spain
:
Univ Hosp Torrevieja, Carretera CV 95 S-N, Alicante 03186, Spain
Martinez-Blanch, J:
Archer Daniels Midland Cobiopolis, Valencia 46980, Spain
Chenoll, E:
Archer Daniels Midland Cobiopolis, Valencia 46980, Spain
Climent, E:
Archer Daniels Midland Cobiopolis, Valencia 46980, Spain
:
Catholic Univ Murcia, MiBioPath Grp, Campus Jeronimos 135, Murcia 30107, Spain
Univ Hosp Vinalopo, Carrer Tonico Sansano Mora 14, Alicante 03293, Spain
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