Electrochemical detection and screening of bladder cancer recurrence using direct electrochemical analysis of urine: A non-invasive tool for diagnosis
Por:
Domenech-Carbo, A, Pontones, J, Domenech-Casasus, C, Artes, J, Villaroya, S and Ramos, D
Publicada:
15 jul 2018
Resumen:
Although detection of urothelial cell carcinoma (or bladder cancer, BC) can be performed via cytological, molecular and genetic marker tests on urine, cystoscopy, an invasive technique, still remains as the gold methodology in clinical practice. It is presented a non-invasive method for detecting BC recurrence consisting of a direct electrochemical test in urine combining voltammetric data at gold and glassy carbon electrodes. The diagnosis is based on the ratio between characteristic voltammetric features recorded for tryptophan, serotonin and melatonin and other related metabolites. The method was tested by means of a clinical trial with 30 patients diagnosed of bladder cancer and a two control groups: 17 healthy volunteers and 15 patients diagnosed of other urinary pathologies and permitted detection of non-muscle invasive stages (pTa, pT1) and muscle-invasive stages (pT2 cancers) of BC. (C) 2018 Elsevier B.V. All rights reserved.
Filiaciones:
Domenech-Carbo, A:
Univ Valencia, Dept Analyt Chem, Dr Moliner 50, E-46100 Valencia, Spain
Pontones, J:
Hosp Univ & Politecn La Fe, Dept Urol, Valencia, Spain
:
Univ Valencia, Dept Analyt Chem, Dr Moliner 50, E-46100 Valencia, Spain
Hosp Requena, Valencia, Spain
Artes, J:
Hosp Univ & Politecn La Fe, Citol Dept, Valencia, Spain
Villaroya, S:
Hosp Univ & Politecn La Fe, Dept Urol, Valencia, Spain
Ramos, D:
Hosp Univ & Politecn La Fe, Dept Pathol, Valencia, Spain
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