Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
Por:
Orti, J, Platero, J, Benlloch, M, Franco-Martinez, L, Tvarijonaviciute, A, Escriba-Alepuz, J and Sancho-Castillo, S
Publicada:
1 may 2021
Resumen:
Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. After 4 months of intervention with 27 MS patients, we observed that Hp does not significantly increase, alongside a significant decrease in IL-6 and a significant increase in muscle percentage. At the same time, Hp synthesis is considerably and positively correlated with IL-6 both before and after treatment; while this correlation occurs significantly reversed with muscle percentage before treatment, no correlation is evident after the intervention. These results seem to indicate that Hp could be a marker of muscle status and could be a diagnosis tool after therapeutic intervention in MS patients.
Filiaciones:
Orti, J:
Catholic Univ Valencia San Vicente Martir, Dept Nursing, Valencia 46001, Spain
Platero, J:
Catholic Univ Valencia San Vicente Martir, Doctoral Degree Sch, Valencia 46001, Spain
Benlloch, M:
Catholic Univ Valencia San Vicente Martir, Dept Nursing, Valencia 46001, Spain
Franco-Martinez, L:
Univ Murcia, Interdisciplinary Lab Clin Anal, Campus Excellence Mare Nostrum, Murcia 30100, Spain
Tvarijonaviciute, A:
Univ Murcia, Interdisciplinary Lab Clin Anal, Campus Excellence Mare Nostrum, Murcia 30100, Spain
:
Sagunto Univ Hosp, Neurophysiol Dept, Valencia 46520, Spain
Inst Sleep Med, Valencia 46021, Spain
Sancho-Castillo, S:
Catholic Univ Valencia San Vicente Martir, Dept Nursing, Valencia 46001, Spain
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