Metabolic and Functional Improvements in a Patient with Charcot-Marie-Tooth Disease Type 2 after EGCG Administration: A Case Report
Por:
Bustos, A, Sabater, P, Benlloch, M, Drehmer, E, Lopez-Rodriguez, M, Platero, F, Platero, J, Escriba-Alepuz, J and Orti, J
Publicada:
1 feb 2021
Categoría:
Medicine (miscellaneous)
Resumen:
Background and objectives: The aim of this study was to report a case of a patient with Charcot-Marie-Tooth disease type 2 (CMT2) treated with epigallocatechin gallate (EGCG) for 4 months in order to assess its therapeutic potential in CMT2. Materials and Methods: The study included a brother and a sister who have CMT2. The sister received 800 mg of EGCG for 4 months, while her brother received placebo for the same period of time. Both participants were assessed before and after daily administration by means of anthropometry; analysis of inflammatory and oxidation markers of interleukin-6 (IL-6) and paraoxonase 1 (PON1) in the blood sample; and motor tests: 2-min walk test (2MWT), 10-m walk test (10MWT), nine-hole peg test (9HPT) and handgrip strength measurement using a handheld Jamar dynamometer. Results: Regarding muscular and motor functions associated with higher inflammation and oxidation, improvements only observed in the woman in all analysed parameters (both biochemical and clinical associated with the metabolism and functionality) after 4 months of treatment with EGCG are noteworthy. Thus, this treatment is proposed as a good candidate to treat the disease.
Filiaciones:
Bustos, A:
Phys Therapy Clin, Valencia 46007, Spain
Sabater, P:
Hosp Riotinto, Huelva 21660, Spain
Benlloch, M:
Catholic Univ Valencia San Vicente Martir, Dept Nursing, Valencia 46001, Spain
Drehmer, E:
Catholic Univ Valencia San Vicente Martir, Dept Basic Sci, Valencia 46900, Spain
Lopez-Rodriguez, M:
Univ Almeria, Dept Nursing Physiotherapy & Med, Almeria 04120, Spain
Platero, F:
Univ Valencia, Dept Med, Valencia 46003, Spain
Platero, J:
Catholic Univ Valencia San Vicente Martir, Dept Nursing, Valencia 46001, Spain
:
Sagunto Univ Hosp, Dept Neurophysiol, Valencia 46520, Spain
Inst Sleep Med, Valencia 46021, Spain
Orti, J:
Catholic Univ Valencia San Vicente Martir, Dept Nursing, Valencia 46001, Spain
Green Published, gold
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