Association between ribs shape and pulmonary function in patients with Osteogenesis Imperfecta
Por:
Sanchis-Gimeno, J, Lois-Zlolniski, S, Gonzalez-Ruiz, J, Palancar, C, Torres-Tamayo, N, Garcia-Martinez, D, Aparicio, L, Perez-Bermejo, M, Blanco-Perez, E, Mata-Escolano, F, Llido, S, Torres-Sanchez, I, Garcia-Rio, F and Bastir, M
Publicada:
1 ene 2020
Categoría:
Multidisciplinary
Resumen:
The aim of the present study was to test the hypothesis that ribs shape changes in patients with OI are more relevant for respiratory function than thoracic spine shape. We used 3D geometric morphometrics to quantify rib cage morphology in OI patients and controls, and to investigate its relationship with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), expressed as absolute value and as percentage of predicted value (% pred). Regression analyses on the full sample showed a significant relation between rib shape and FEV1, FVC and FVC % pred whereas thoracic spine shape was not related to any parameter. Subsequent regression analyses on OI patients confirmed significant relations between dynamic lung volumes and rib shape changes. Lower FVC and FEV1 values are identified in OI patients that present more horizontally aligned ribs, a greater antero-posterior depth due to extreme transverse curve at rib angles and a strong spine invagination, greater asymmetry, and a vertically short, thoracolumbar spine, which is relatively straight in at levels 1-8 and shows a marked kyphosis in the thoraco-lumbar transition. Our research seems to support that ribs shape is more relevant for ventilator mechanics in OI patients than the spine shape. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Cairo University.
Filiaciones:
:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
Lois-Zlolniski, S:
CSIC, Jose Gutierrez Abascal 2, E-28006 Madrid, Spain
Gonzalez-Ruiz, J:
CSIC, Jose Gutierrez Abascal 2, E-28006 Madrid, Spain
Palancar, C:
CSIC, Jose Gutierrez Abascal 2, E-28006 Madrid, Spain
Torres-Tamayo, N:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
CSIC, Jose Gutierrez Abascal 2, E-28006 Madrid, Spain
Garcia-Martinez, D:
CSIC, Jose Gutierrez Abascal 2, E-28006 Madrid, Spain
Aparicio, L:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
Perez-Bermejo, M:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
Blanco-Perez, E:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
Univ Hosp La Ribera, Dept Radiol, Carretera Corbera Km 1, Valencia 46600, Spain
Mata-Escolano, F:
ASCIRES ERESA Campanar Grp, CT & MRI Unit, Avda Campanar 114, Valencia 46015, Spain
Llido, S:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
Torres-Sanchez, I:
Hosp La Paz Inst Hlth Res IdiPAZ, Paseo De La Castellana 261, Madrid 28046, Spain
Garcia-Rio, F:
Hosp La Paz Inst Hlth Res IdiPAZ, Paseo De La Castellana 261, Madrid 28046, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Calle Monforte Lemos 3-5, Madrid 28029, Spain
Bastir, M:
Univ Valencia, Fac Med, Dept Anat & Human Embryol, Giaval Res Grp, Av Blasco Ibanez 15, E-46010 Valencia 46010, Spain
CSIC, Jose Gutierrez Abascal 2, E-28006 Madrid, Spain
Green Published, gold
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